Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

By Katrin Kierdorf, Daniel Erny, Tobias Goldmann, Victor Sander, Christian Schulz, Elisa Gomez Perdiguero, P. Wieghofer, Annette Heinrich, P. Riemke, C. Hölscher and 12 more. Nature Neuroscience, 2013

1,365 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/eb4f4608607fdfaa1984eeb284913f44ff29bbc0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Florent Ginhoux
2. David V. Hansen
3. B. Barres

In Immunology

1. M. Guilliams
2. Florent Ginhoux
3. P. Italiani
4. D. Boraschi
5. A. Mildner
6. Steffen Jung
7. C. Varol
8. Chao Gao

In Neurology

1. Alok Kumar
2. Chao Gao
3. Shengdi Chen
4. Yuyan Tan
5. Jingwen Jiang
6. M. Guilliams
7. Qingyun Li
8. M. O’Banion

Citations in the corpus

• Microglia in the TBI Brain: The Good, The Bad, And The Dysregulated (2015, background): “Microglia development is dependent on Pu.1 and Irf8 transcription factors (Kierdorf et al., 2013), whereas essential bone-marrow derived macrophage transcription factors Myb and colony-stimulating factor 1 (CSF1) are not required (Schulz et al., 2012).”
• iPSC-derived human microglia-like cells to study neurological diseases (2017, neutral): “EMPs further develop to early primitive macrophages that migrate into the developing neural tube, and become microglial progenitors (Kierdorf et al., 2013, Prinz and Priller, 2014).”
• Origin and differentiation of microglia (2013, background): “First, the conservation of primitive macrophages and their YS derivation throughout evolution and across diverse species suggests that microglia play an important physiological role in the development of the CNS.”
• A neurodegeneration-specific gene expression signature and immune profile of acutely isolated microglia from an ALS mouse model (2013, neutral): “Unlike other nervous system cells that derive from the ectoderm, recent work has shown that microglia originate from erythromyeloid progenitors during embryonic hematopoiesis (Alliot et al., 1991; Ginhoux et al., 2010; Kierdorf et al., 2013; Schulz et al., 2012).”
• Macrophages: development and tissue specialization. (2015, background): “Alternatively, embryonic yolk sac macrophages might be uniquely able to infiltrate the neuroectoderm, owing to their expression repertoire of matrix metalloproteinases or chemokine receptors (43).”
• Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia (2013, neutral): “Specifically, it has been shown that adult microglia derive from primitive macrophages 4 in a Myb-independent manner 5 via PU.1 and IRF8 dependent pathways 6 .”
• The biphasic function of microglia in ischemic stroke (2017, neutral): “When PU.1 and IRF8 are deficient, the number of Iba1+ microglia decreased in mouse brain (Kierdorf et al., 2013).”
• Microglia and macrophages in brain homeostasis and disease (2017, background): “A1 and A2 yolk sac (YS) macrophages were defined by Kierdorf et al.(14).”