The glucocorticoid receptor: rapid exchange with regulatory sites in living cells.

By James G. McNally, W. G. Müller, D. Walker, R. Wolford, G. Hager. Science, 2000

835 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/62816bebf9077052d63da818ee7addc3156462cc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. B. O’Malley
2. Carolyn L. Smith
3. K. Prasanth
4. David L. Spector
5. J. Cidlowski

In Genetics

1. B. O’Malley
2. R. Singer
3. Carolyn L. Smith
4. J. Cidlowski
5. R. Tjian
6. C. Alberini

In Molecular Biology

1. B. O’Malley
2. Y. Shav-Tal
3. Donald E. Ingber
4. B. Lemon
5. R. Singer
6. Bart Staels
7. B. Sprague
8. Ravi Sachidanandam

Citations in the corpus

• From silencing to gene expression: real-time analysis in single cells. (2004, background): “…chromatin in living cells but also to show that transcriptional activators assemble into dynamic complexes atWe have developed an inducible system to visualize transcription sites (McNally et al., 2000; Muller et al.,gene expression at the levels of DNA, RNA and protein 2001).in living cells.”
• The Biology of the Glucocorticoid Receptor: New Signaling Mechanisms in Health and Disease (2013, background): “The interaction of GR with DNA is highly dynamic, with GR cycling between bound and unbound states every few seconds (33).”
• Orchestrated response: a symphony of transcription factors for gene control. (2000, background): “Biological systems are dynamic and transcription factors likely only transiently associate with their cognate DNA recognition sites and co-factor targets (McNally et al. 2000).”
• Analysis of binding reactions by fluorescence recovery after photobleaching. (2004, background): “Indeed most recent FRAP experiments seek to infer something about how the GFP-tagged protein interacts with binding sites within the cell (e.g., McNally et al., 2000; Phair and Misteli, 2000).”
• Coregulator function: a key to understanding tissue specificity of selective receptor modulators. (2004, background): “Although the rapid kinetics of receptor and coactivators are evident in cellular imaging experiments (95, 135), it is unknown what controls the dynamic association of nuclear receptors and coregulators with target genes, or whether these processes can be regulated in a cell-specific fashion.”
• Overview of Nomenclature of Nuclear Receptors (2006, background): “…fluorescent proteins, has shown that NRs are highly mobile in the nucleus with a rapid exchange of receptor molecules on DNA, which can be measured in seconds (McNally et al., 2000; Maruvada et al., 2003; Schaaf and Cidlowski, 2003; Hager et al., 2004; Nagaich et al., 2004; Rayasam et al., 2005).”
• Beyond the sequence: cellular organization of genome function. (2007, neutral): “…bind to their specific response elements in the promoter regions of target genes with residence times on the order of only a few seconds (McNally et al., 2000; Stenoien et al., 2001), and several of their interaction partners bind equally transiently to the promoter (Becker et al.,…”