Coregulator function: a key to understanding tissue specificity of selective receptor modulators.

By Carolyn L. Smith, B. O’Malley. Endocrine reviews, 2004

962 citations recorded by the source corpus.

Subfields: Genetics, Oncology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/d2d3d4c66b0048ab234789a03f5a997fe8bc5b2c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Christopher K. Glass
2. Jan-Ake Gustafsson
3. Hannelore V. Heemers
4. D. Tindall
5. D. Bikle

In Oncology

1. Jan-Ake Gustafsson
2. Christopher K. Glass
3. Hannelore V. Heemers
4. D. Tindall

In Pharmacology

1. Hannelore V. Heemers
2. D. Tindall

Citations in the corpus

• Overview of Nomenclature of Nuclear Receptors (2006, background): “Ligands with such characteristics have been developed for a number of NRs, such as ERs (SERM), AR (selective AR modulator), and PPARs (selective PPAR modulator) (Smith and O’Malley, 2004).”
• The different roles of ER subtypes in cancer biology and therapy (2011, background): “and SRC1 and ERα mRNA levels correlate in endometrial carcinoma tissue, suggesting that the SRC1–ERα protein interaction may account for the adverse effects of tamoxifen during endometrial carcinogenesi”
• Estrogen signaling multiple pathways to impact gene transcription. (2006, background): “There are differences between the relative affinities of ER and ER for members of the p160 coactivator family [13, 88].”
• The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. (2012, background): “Nuclear hormone receptors including the VDR are further regulated by protein complexes that can be activators or repressors (15, 16).”
• Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. (2005, background): “…of California, San Diego 9500 Gilman Drive La Jolla, California 92093 4Exelixis, Inc. San Diego, California 92121 5Department of Chemistry and Biochemistry 6Department of Medicine Howard Hughes Medical Institute University of California, San Diego 9500 Gilman Drive La Jolla, California 92093”
• Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex. (2007, result): “In contrast, other models appear to be phenotypically normal, suggesting that the function of the coregulator that is being targeted may overlap with and be rescued by the action of other cofactors (347).”