Protein Synthesis and Neurotrophin-Dependent Structural Plasticity of Single Dendritic Spines

By J. Tanaka, Yoshihiro Horiike, Masanori Matsuzaki, Takashi Miyazaki, G. Ellis‐Davies, Haruo Kasai. 2008

654 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

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Citations in the corpus

Direct current stimulation promotes BDNF-dependent synaptic plasticity: Potential implications for motor learning (2010, positive): “Moreover, protocols used to induce STDP were reported to increase BDNF secretion (Tanaka et al., 2008).”
COORDINATION OF SIZE AND NUMBER OF EXCITATORY AND INHIBITORY SYNAPSES RESULTS IN A BALANCED STRUCTURAL PLASTICITY ALONG MATURE HIPPOCAMPAL CA1 DENDRITES DURING LTP (2011, background): “…experiments have aimed to understand whether an individual dendritic spine can undergo structural plasticity in response to localized chemical induction (Engert and Bonhoeffer, 1999), glutamate uncaging (Matsuzaki et al., 2004; Tanaka et al., 2008), or minimal stimulation (Lang et al., 2004).”
Post-synaptic BDNF-TrkB Signaling in Synapse Maturation, Plasticity and Disease (2010, positive): “However, a recent study provides further evidence supporting a critical role of BDNF and protein synthesis in hippocampal neuron spine growth (Tanaka et al., 2008).”
Structural and molecular remodeling of dendritic spine substructures during long-term potentiation (2014, result): “…neurotrophic factor (BDNF), known to trigger local translation and promote L-LTP (Minichiello, 2009), facilitated the spine enlargement, consistent with a previous report (Tanaka et al., 2008) and, concomitantly, enhanced and accelerated (to phases I and II) the accumulation of Homer1b (Figure 8E).”
BDNF — a key transducer of antidepressant effects (2015, background): “Moreover, LTP-induced enlargement of hippocampal dendritic spine volume is dependent on BDNF signaling and local protein translation (Tanaka et al., 2008).”
Modeling the dynamic interaction of Hebbian and homeostatic plasticity. (2014, background): “…on the fact that BDNF/TrkB signaling is required for growth of synapses in neuronal cell culture (Meyer-Franke et al., 1998) and for stabilization of LTP in hippocampus (Tanaka et al., 2008; Kovalchuk et al., 2002; Figurov et al., 1996; Lai et al., 2012) and visual cortex (Sermasi et al., 2000).”
BDNF-induced local protein synthesis and synaptic plasticity. (2014, positive): “BDNF may contribute to some of these alterations since the sustained enlargement of synaptic spines at the hippocampal CA3-CA1 synapses in response to LTP-inducing synaptic stimulation was shown to depend on endogenous BDNF and required protein synthesis (Tanaka et al., 2008).”
TrkB signalling pathways in LTP and learning (2009, background): “Furthermore, the release of endogenous BDNF from single neurons following the pairing of repetitive postsynaptic spikes with two-photon uncaging of glutamate at single spines has been demonstrate”
Making memories last: the synaptic tagging and capture hypothesis (2010, background): “This revised STC hypothesis explains why this BDNF-dependent tagging can be independent of the immediate expression of LT”