T cell anergy.

By Ronald H. Schwartz. Annual Review of Immunology, 2003

1,592 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/6163bffb715e830b4bc829f711a6aac062fc69e7

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In Immunology

Citations in the corpus

Regulation of Immune Responses by mTOR (2011, background): “Initial models proposed that T cell anergy was the result of TCR engagement in the absence of proliferation and that IL-2-induced proliferation could reverse anergy (50).”
STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. (2005, background): “Because SOC influx has been shown to be required for T cell activation [6, 17], we also examined the effect of STIM1 on Ca2+ influx in a Jurkat T lymphocyte model.”
Overcoming T cell exhaustion in infection and cancer (2015, background): “This feature distinguishes exhaustion from other types of T cell dysfunction such as anergy, a state of hyporesponsiveness where cells fail to acquire effector functions because of priming in the absence of adequate costimulation and/or inflammation [56].”
Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control (2008, positive): “A number of stimuli have been reported to overcome the anergic state (reviewed in Schwartz, 2003).”
Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK Responses (2005, background): “A third possibility is that such fluctuations do result in an occasional T cell producing potential activation signals upon self-recognition; however, in the non-inflamed state, this would lead to tolerance through deletion or anergy [56].”
T cell anergy, exhaustion, senescence and stemness in the tumor microenvironment (2013, background): “It is generally accepted that T cells that are presented antigen along with suboptimal CD28 co-stimulation [4,5] and/or high co-inhibition [17] result in anergic phenotypes, as characterized by their low IL-2 production and cell cycle arrest”
Computational Immunology Meets Bioinformatics: The Use of Prediction Tools for Molecular Binding in the Simulation of the Immune System (2010, background): “xi) T cell anergy [61]; xii) Matzinger’s danger signals [62]; xiii) Idiotypic Network theory [63].”
Pattern recognition receptors and control of adaptive immunity (2009, background): “One aspect of peripheral tolerance is the inactivation of T cells that see their antigen in the absence of signals indicating the presence of infection; these cells are thus rendered permanently unresponsive or anergic (6).”