Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
By Mayumi Ito, Zaixin Yang, T. Andl, C. Cui, Noori Kim, S. Millar, G. Cotsarelis. Nature, 2007
986 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology, Urology
View Paper: https://www.semanticscholar.org/paper/6125df582aee5c60b5381b09dccb15dd6b5d9b61
How researchers see this paper
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In Cell Biology
In Molecular Biology
- Hans Clevers
- C. Blanpain
- Elaine Fuchs
- S. Morrison
- A. Spradling
- Hugo J. G. Snippert
- Paul Martin
- T. Shaw
In Urology
- Hans Clevers
- Elaine Fuchs
- C. Blanpain
- S. Morrison
- A. Spradling
- Hugo J. G. Snippert
- Paul Martin
- V. Horsley
Citations in the corpus
- Wound healing: cellular mechanisms and pathological outcomes (2020, background): “However, under specific circumstances wound-induced follicle neo-genesis can occur, seemingly via re-activation of developmental Wnt and Shh signalling [60].”
- Wound repair at a glance (2009, background): “Appendages do not readily develop within a scar, but it has been reported that inflammation can promote appendage re-growth (Osaka et al., 2007), and this is thought to require re-enactment of the epidermal developmental program, in which Wnt signalling has a pivotal role (Ito et al., 2007).”
- Epidermal homeostasis: a balancing act of stem cells in the skin (2009, background): “During severe injury, a Wnt-dependent wound signal can induce local de novo HF formation from the IFE, thereby recapitulating embryonic HF developmen”
- Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “The ability to activate facultative niches is not limited to the hematopoietic system as injury of adult skin can lead to the formation of new hair follicles that become colonized by stem cells (Ito et al., 2007).”
- Tracking adult stem cells (2011, background): “…assays, as these cells can heal full-thickness wounds in the dorsal skin of mice by generating progeny for all three skin lineages (Morris et al, 2004; Blanpain et al, 2004; Jaks et al, 2008; Jensen et al, 2009), although their contribution to wound healing is only transient (Ito et al, 2007).”
- Wound healing and skin regeneration. (2015, background): “Mouse models with small punch wounds ( 6 mm) heal largely by contraction (note that contraction accounts for 90% of repair of mouse skin), while hair follicles fail to regenerate in the wound site (Ito et al. 2007).”
- Cellular and molecular mechanisms of skin wound healing (2024, positive): “Follicle neogenesis after wounding is dependent on Wnt signalling as mice expressing the Wnt inhibitor DKK1 in their epithelial cells 59 or those lacking epithelial expression of Wntless 60 display impaired hair follicle neogenesis while otherwise exhibiting normal wound closure.”