VISA is an adapter protein required for virus-triggered IFN-beta signaling.

By Liang-Guo Xu, Yan-Yi Wang, Ke-jun Han, Lianyun Li, Z. Zhai, H. Shu. Molecules and Cells, 2005

1,973 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6119ca00f00f4b1b9affbfa0594ee6e6955c77fa

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Citations in the corpus

Anti-immunology: evasion of the host immune system by bacterial and viral pathogens. (2006, background): “…sentinel for virus infection (Yoneyama et al., 2004) that signals via a mitochondrial checkpoint (Freundt and Lenardo, 2005; Seth et al., 2005; Xu et al., 2005), but the link between virus infection and TLR signaling is very cell specific and needs to be better defined in terms of the…”
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by RIG-I (2009, background): “…the cytosolic receptor RIG-I recognizes viral RNA in a 50-triphosphate-dependent manner and initiates an antiviral signaling cascade by interacting with the downstream partner MAVS/ VISA/IPS-1/Cardif (Cui et al., 2008); (Kawai et al., 2005; Meylan et al., 2005; Seth et al., 2005; Xu et al., 2005).”
Regulation and Function of IKK and IKK-Related Kinases (2006, neutral): “Interaction of IPS-1 with TBK1 in HEK293 cells has been described in one publication (186), but not confirmed (184), implying either low affinity or indirect interaction between the two.”
Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity (2007, background): “Signaling by each occurs through homotypic caspase activation and recruitment domain (CARD) interactions with the interferon promoter-stimulating factor 1 (IPS-1) adaptor protein (19, 27, 35, 39 ), which recruits RIG-I and MDA5 to the outer membrane of the mitochondria as part of a macromolecular s”
Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling (2009, positive): “The authors further demonstrated that the Atg5-Atg12 conjugate directly associates with RIG-I, MDA-5 and the adaptor protein IFN- promoter stimulator 1 (IPS-1) (17–20)—also known as mitochondrial antiviral signaling (19), Cardif (21), or virusinduced signaling adaptor (20)—through the caspase recrui”
NLRP3 (NALP3/CIAS1/Cryopyrin) mediates key innate and healing responses to influenza A virus via the regulation of caspase-1 (2009, positive): “The ssRNA influenza virus genome has been shown to activate the TLR7 and RIG-I pathways in APCs such as macrophages and dendritic cells (Diebold et al., 2004; Pichlmair et al., 2006).”
Type I interferons in host defense. (2006, positive): “Both RIG-I and MDA5 use the CARD-containing adaptor protein MAVS (also known as IPS-1, VISA, or CARDIF) to activate the IFNb gene (Kawai et al., 2005; Meylan et al., 2005; Seth et al., 2005; Xu et al., 2005).”