From pathogenesis to treatment of chronic lymphocytic leukaemia

By T. Zenz, D. Mertens, Ralf Küppers, H. Döhner, S. Stilgenbauer. Nature Reviews. Cancer, 2010

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Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia (2011, background): “ppt"/> Chronic lymphocytic leukaemia (CLL), the most frequent leukaemia in adults in Western countries, is a heterogeneous disease with variable clinical presentation and evolutio”
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia (2011, neutral): “1032" language="eng" relation="no"> Here we perform whole-exome sequencing of samples from 105 individuals with chronic lymphocytic leukemia (CLL”
Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation (2011, background): “…clinical heterogeneity of the disease or the development of severe complications, such as RS trans formation and chemorefractoriness, which, despite recent ad vances, still represent unmet clinical needs (Rossi and Gaidano, 2009; Tam and Keating, 2010; Zenz et al., 2010b; Fangazio et al., 2011).”
Multi‐Omics Factor Analysis—a framework for unsupervised integration of multi‐omics data sets (2018, background): “First, in the CLL study, we demonstrated that our method is able to identify major drivers of variation in a clinically and biologically heterogeneous disease.”