B cells in HIV infection and disease

By S. Moir, A. Fauci. Nature reviews. Immunology, 2009

714 citations recorded by the source corpus.

In recent years, intense research efforts have been dedicated to elucidating the pathogenic mechanisms of HIV-associated disease progression. In addition to the progressive depletion and dysfunction of CD4+ T cells, HIV infection also leads to extensive defects in the humoral arm of the immune system. The lack of immune control of the virus in almost all infected individuals is a great impediment to the treatment of HIV-associated disease and to the development of a successful HIV vaccine. This Review focuses on advances in our understanding of the mechanisms of B-cell dysfunction in HIV-associated disease and discusses similarities with other diseases that are associated with B-cell dysfunction.

Subfields: Epidemiology, Immunology, Virology

View Paper: https://www.semanticscholar.org/paper/c1f8005deee16c877bd6f3a29a6827387d2f3caf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. F. Sallusto
2. Rafi Ahmed
3. K. Araki
4. A. Lanzavecchia

In Immunology

1. Rafi Ahmed
2. F. Sallusto
3. A. Lanzavecchia
4. K. Araki
5. Bali Pulendran
6. E. Wherry
7. S. Kaech
8. V. Schirrmacher

In Virology

1. F. Sallusto
2. Rafi Ahmed
3. K. Araki
4. A. Lanzavecchia

Citations in the corpus

• From Vaccines to Memory and Back (2010, positive): “…not from viruses of a different serotypes (Green and Rothman, 2006; Halstead, 2007; Subbarao and Joseph, 2007), while in the case of HIV-1 a rapid diversification of the transmitted virus makes the immune response ineffective (Johnston and Fauci, 2007; McMichael et al., 2010; Moir and Fauci, 2009).”