15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.
By Daniel S. Straus, G. Pascual, Mei Li, J. Welch, M. Ricote, C. Hsiang, L. L. Sengchanthalangsy, G. Ghosh, C. Glass. Proceedings of the National Academy of Sciences of the United States of America, 2000
1,009 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/5f82da6871772d74f72f88a0c8813885413d5643
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Citations in the corpus
- Pro-Resolving lipid mediators and Mechanisms in the resolution of acute inflammation (2014, background): “…nuclear receptor PPAR-γ (Khan, 1995), decreases pro-inflammatory cytokine release and modifies gene expression (Ricote et al., 1998) as well as directly inhibits the actions of IκB kinase (IKK), the kinase responsible for the activation of NF-κB (Cernuda-Morollon et al., 2001; Straus et al., 2000).”
- Inflammatory Resolution: new opportunities for drug discovery (2004, neutral): “cgi?l=4790">NF-κB , AP1 and SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION (STATs”
- Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition (2004, background): “This anti-inflammatory activity may be mediated, at least in part, by inhibition of I B kinase (Straus et al., 2000).”