Role of linker histone in chromatin structure and function: H1 stoichiometry and nucleosome repeat length

By C. Woodcock, A. Skoultchi, Yuhong Fan. 2006

483 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Plant Science

A. Bird

Citations in the corpus

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps (2010, background): “H1 promotes the condensed, closed state of chromatin, which restricts its accessibility (Roche et al., 1985; Bustin et al., 2005; Woodcock et al., 2006).”
Organization of Chromatin by Intrinsic and Regulated Phase Separation (2019, background): “Across a number of organisms, cell types, and biochemical reconstitutions, the expression level of linker histone and internucleosome linker length are linearly related (Woodcock et al., 2006).”
Structural Mechanisms of Nucleosome Recognition by Linker Histones (2015, background): “The abundance of linker histones in the nucleus approaches that of the nucleosome in somemetazoan cells (Bates and Thomas, 1981; Woodcock et al., 2006), suggesting that the chromatosome could be the repeating structural unit of chromatin.”
Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation. (2005, background): “We find a robust linear relationship between NRL and H1/nucleosome (linear regression r2 = 0.95) over the range c. from 0.25 to 0.80 H1 per nucleosome (Woodcock et al., 2006).”
ACF catalyses chromatosome movements in chromatin fibres (2008, background): “Despite their severe impact on chromatin structure and their high abundance in the nucleus—approximately one H1 per nucleosome in typical eukaryotic nuclei (Woodcock et al, 2006)—their effect on chromatin remodelling has only been addressed in a handful of studies and remains controversial.”
Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1. (2017, background): “Linker histones are a key determinant of nucleosome repeat length (Woodcock et al., 2006) and are critical for the assembly and maintenance of the 30 nm chromatin fiber (Bednar et al.”
Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms (2020, background): “The chromatosome is the predominant repeating structural unit of metazoan chromatin because of the existence of an abundance of linker histones in the nucleus (Woodcock et al., 2006).”
Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state (2010, background): “Mole Histone H1 is present in most cell types at an approximate stoichiometry of one molecule per nucleosome (Woodcock et al., 2006), but uniquely, in neurons, this is reduced to one molecule every two nucleosomes (Allan et al.”
ChromEMT: Visualizing 3D chromatin structure and compaction n interphase and mitotic cells (2017, unknown): “Each DNA-nucleosome particle is separated by 20 to 75 bp of DNA that can bind to histone H1 (3).”