Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation.

By Yuhong Fan, Tatiana Nikitina, Jie Zhao, Tomara J. Fleury, Riddhi Bhattacharyya, E. Bouhassira, A. Stein, C. Woodcock, A. Skoultchi. 2005

595 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

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Citations in the corpus

Precise genome-wide mapping of single nucleosomes and linkers in vivo (2018, background): “7c), in agreement with observations from multicellular organisms, where histone H1 and its variants have an important role in nucleosome spacing [74, 75].”
Organization of Chromatin by Intrinsic and Regulated Phase Separation (2019, background): “These data suggest that correlations between nucleosome linker length and histone H1 expression levels across many eukaryotes (Fan et al., 2005; Woodcock et al., 2006), may reflect cellular efforts to maintain homeostasis of genome compaction.”
Gene-specific H1 eviction through a transcriptional activator-p300-NAP1-H1 pathway (2019, background): “effects on transcription (Fan et al., 2005), likely due to H1 variant redundancy and compensatory increases in total H1, a later study showed a deficiency in repression of pluripotency genes during differentiation of these cells (Zhang et al.”
The nucleosome remodeler DDM1 allows DNA methyltransferases to access H1-containing heterochromatin (2013, background): “Mice with reduced H1 specifically lose DNA methylation at the regulatory regions of several imprinted genes (Fan et al., 2005), whereas loss of H1 leads to extensive hypermethylation in the fungus Ascobolus immersus (Barra et al., 2000) and apparently stochastic methylation gains and losses in…”
The ISW1 and CHD1 ATP-dependent chromatin remodelers compete to set nucleosome spacing in vivo (2016, background): “Although H1 content and nucleosome spacing are correlated in vitro (20,27) and in vivo (28,55), loss of H1 does not have a global effect on spacing in yeast (47,56).”
Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms (2020, background): “, 2018; Hergeth and Schneider, 2015), including gene expression (Fan et al., 2005; Shen and Gorovsky, 1996), mitotic chromosome architecture and segregation (Maresca et al.”
The genomic landscape of the somatic linker histone subtypes H1.1 to H1.5 in human cells. (2013, background): “However, inactivation of three somatic H1 subtypes in mice demonstrated that correct H1 levels are critical for proper development and that 50% reduction of H1 is earlyembryonic lethal (Fan et al., 2005).”
Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma (2013, unknown): “These encode proteins that facilitate the folding of higher-order chromatin structures and regulate access of histone-modifying enzymes and chromatin remodeling complexes to their target genes 17-19 .”