Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells

By V. Ramiya, Michael Maraist, K. Arfors, D. Schatz, A. Peck, J. Cornelius. Nature Medicine, 2000

729 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/5d90d3c8e8bb58e32adc6084e5993224336ae22d

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In Genetics

1. Hans Clevers
2. H. Begthel
3. Toshiro Sato
4. M. van de Wetering
5. Nick Barker
6. R. Nusse
7. Pengfei Lu

In Surgery

1. Hans Clevers
2. Guoqiang Gu
3. Jolanta Dubauskaite
4. D. Melton

Citations in the corpus

• Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. (2002, background): “There is considerable interest in the possibility of growing pancreatic islets for the treatment of diabetes (Bonner-Weir et al., 2000; Ramiya et al., 2000; Soria et al., 2000).”
• In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. (2003, background): “Multipotent stem cells have been described within pancreatic islets (11, 12) and in nonendocrine compartments of the pancreas (9, 13), and these cells have the capacity to differentiate into pancreatic islet-like structures in vitro.”
• Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis (2013, positive): “…populations of pancreas cells have been previously established and typically include factors such as EGF, HGF and Nicotinamide (Bonner-Weir et al , 2000; Ramiya et al , 2000; Deutsch et al , 2001; Seaberg et al , 2004; Rovira et al , 2010; Cardinale et al , 2011; Smukler et al , 2011).”
• Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. (2001, methodology): “A notable exception was transthyretin, a liver acute-phase protein (34) that was expressed only in NIP cell cultures treated with dexamethasone.”
• β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas (2008, background): “, 2004) that under certain conditions were able to reverse hyperglycemia when transplanted in diabetic mice (Hao et al., 2006; Ramiya et al., 2000).”