Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes.

By H. Zulewski, E. Abraham, M. Gerlach, P. Daniel, W. Moritz, Beat Müller, Mario Vallejo, M. K. Thomas, J. Habener. Diabetes, 2001

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Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential (2004, methodology): “Cells were treated according to a sequential protocol of specification, commitment and differentiation with factors known to promote the expression of a β-like cell phenotype in other systems (Movassat et al., 2002; Hunziker and Stein, 2000; Zulewski et al., 2001; Lumelsky et al., 2001).”
Neural stem and progenitor cells in nestin‐GFP transgenic mice (2004, background): “In addition, nestin expression has been reported in several other tissues and cell types, e.g., pancreatic islets, and the developing testis, tongue, tooth, and heart (Kachinsky et al., 1995; Terling et al., 1995; Hunziker and Stein, 2000; Zulewski et al., 2001).”
Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies (2007, background): “Experiments aimed at differentiating different human extra-hepatic stem cells to hepatocytes have been performed by a relatively large number of groups (Avital et al., 2001; Eberhardt et al., 2006; Fiegel et al., 2003; Lavon et al., 2004; Lee et al., 2004; von Mach et al., 2004; Zulewski et al., 200”