Structure and Function of the Skeletal Muscle Extracellular Matrix

By Allison R Gillies, R. Lieber. Muscle and Nerve, 2011

903 citations recorded by the source corpus.

The skeletal muscle extracellular matrix (ECM) plays an important role in muscle fiber force transmission, maintenance, and repair. In both injured and diseased states, ECM adapts dramatically, a property that has clinical manifestations and alters muscle function. Here we review the structure, composition, and mechanical properties of skeletal muscle ECM; describe the cells that contribute to the maintenance of the ECM; and, finally, overview changes that occur with pathology. New scanning electron micrographs of ECM structure are also presented with hypotheses about ECM structure–function relationships. Detailed structure–function relationships of the ECM have yet to be defined and, as a result, we propose areas for future study. Muscle Nerve 44: 318–331, 2011

Subfields: Biomedical Engineering, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/fc90450ccaf8b44ee7fb2e4f73e3a2594f96bad8

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In Biomedical Engineering

1. Deok‐Ho Kim
2. Hong Nam Kim
3. Tom Ben-Arye
4. S. Levenberg

In Molecular Biology

1. Deok‐Ho Kim
2. Tom Ben-Arye
3. S. Levenberg

Citations in the corpus

• Tissue Engineering for Clean Meat Production (2019, background): “The majority of skeletal muscle tissue ECM is deposited and remodeled by fibroblasts (Figure 1) (Kjaer, 2004; Gillies and Lieber, 2011; Mackey et al., 2017).”
• Nanotopography-guided tissue engineering and regenerative medicine (2012, background): “thick ECM layer termed the perimysium [199].”