Spatial relational memory requires hippocampal adult neurogenesis

By Abrous Nora. 2009

268 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5d0dc4381150cc206186feb331e7e58659647279

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In Cognitive Neuroscience

Citations in the corpus

Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. (2009, background): “…irradiation [Snyder et al. 2005] or diphtheria toxin-based ablation of new neurons [Imayoshi et al. 2008]) or even impairment in the acquisition phase of spatial learning (using genetic ablation of TLX or transgenesis-mediated ablation of newborn cells) (Dupret et al. 2008; Zhang et al. 2008).”
The role of adult hippocampal neurogenesis in brain health and disease (2018, background): “However, there are a few reports of neurogenesis knockdown impairing the initial acquisition of the Morris water maze [73] or contextual fear conditioning [74, 75], and increasing neurogenesis via running does not universally lead to improvement [76].”
Fragile X Mental Retardation Protein Regulates Proliferation and Differentiation of Adult Neural Stem/Progenitor Cells (2010, background): “More recent direct evidence has come from inducing the death of new neurons in the hippocampus [17–19] and from inhibiting the Wnt signaling pathway in the hippocampus using retrovirus [20].”
Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation (2011, background): “Similarly, variability in apparatus settings and testing paradigms may have different demands for memory resolution, which could help explain the detection of behavioral phenotypes in some cases but not others (Dupret et al., 2008; Garthe et al., 2009; reviewed by Deng et al., 2010).”
Computational influence of adult neurogenesis on memory encoding. (2009, unknown): “For example, at least three separate studies have demonstrated that rodents with reduced neurogenesis showed impaired performance on the Morris water maze (Dupret et al., 2008; Snyder et al., 2005; Zhang et al., 2008), but no differences in water maze performance were seen in several other studies u”
Pattern separation: a common function for new neurons in hippocampus and olfactory bulb (2011, unknown): “Recent studies showing a role for adult-born neurons in such tasks are consistent with the idea that neurogenesis contributes to pattern separation (Dupret et al., 2008; Garthe et al., 2009; Wojtowicz et al., 2008).”