PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

By M. Pearson, R. Carbone, Carla Sebastiani, M. Cioce, M. Fagioli, Shinichi Saito, Y. Higashimoto, E. Appella, S. Minucci, P. Pandolfi and 1 more. Nature, 2000

892 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/5d088a38be85dcdf82b23225bb1d8fb0f1b2c277

How researchers see this paper

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In Molecular Biology

1. W. Gu
2. Xiang-Jiao Yang
3. C. Brooks
4. E. Seto
5. E. Verdin
6. W. Dröge
7. Martin F. Lavin
8. N. Gueven

In Oncology

1. W. Gu
2. C. Brooks
3. E. Seto
4. Xiang-Jiao Yang
5. W. Dröge
6. Martin F. Lavin
7. N. Gueven
8. E. Verdin

Citations in the corpus

• The complexity of p53 stabilization and activation (2006, background): “Acetylation of p53 has also been linked to its localization to promyelocytic leukaemia (PML) bodies.(33) Interaction of p53 with Sir2, an NAD-dependent histone deaceylase, could provide a mechanism for downregulation of p53.”
• Sirtuins: critical regulators at the crossroads between cancer and aging (2007, background): “Increased p53 acetylation is associated with senescence (Pearson et al., 2000).”
• The promise of retinoids to fight against cancer (2001, background): “63 ) and regulates the p53 response to oncogenic signal”
• Mechanisms of action of arsenic trioxide. (2002, background): “The biochemical basis of this dependence is provided in recent experiments showing that ras-induced p53 acetylation is lost in cells that do not express PML (35).”
• Cellular senescence and its effector programs (2014, background): “…oncogenic domains [PODs]), is a marker of senescence: During senescence, PML is up-regulated, the size and number of PML NBs are increased (Table 1), and PML contributes to senescence through regulation of p53 and Rb status (Ferbeyre et al. 2000; Pearson et al. 2000; Bischof et al. 2002, 2005).”
• Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2 (2002, methodology): “c, GST–p53(1-80) or a point mutant of this fusion protein containing a Ser 46 to alanine exchange were employed as substrate proteins, typical autoradiograms are displayed.”
• Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. (2003, background): “Furthermore, PML and oncogenic Ras can upregulate acetylated p53 levels in primary fibroblasts [79].”
• Targeting p53 pathways: mechanisms, structures and advances in therapy (2023, background): “p53 also activates the transcription of genes that encode promyelocytic leukemia protein, leading to cellular senescence.(89)”
• Lysine acetylation: codified crosstalk with other posttranslational modifications (2008, background): “In addition, oncogenic Ras and a variety of stress-inducing agents promote p53 acetylation (Pearson et al., 2000; Ito et al., 2001).”