Mutations induced by ultraviolet light.
By G. Pfeifer, Y. You, A. Besaratinia. Mutation research, 2005
769 citations recorded by the source corpus.
Subfields: Dermatology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/5c8b0e3b9dd2c2b5e3509a9427fe960b99a8d5aa
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In Dermatology
In Molecular Biology
- S. Nik-Zainal
- Michael R. Stratton
- Ludmil B. Alexandrov
- J. Wagner
- David C. Wedge
- J. Cadet
- A. Richardson
- Graham C. Walker
Citations in the corpus
- Comprehensive Analysis of Hypermutation in Human Cancer (2017, positive): “UV light is the primary cause of the high numbers of mutations in malignant melanoma (Pfeifer et al., 2005; Sage, 1993).”
- DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation. (2013, background): “5-Methylcytosine is very susceptible to UVB radiation (Pfeifer et al. 2005).”
- Signatures of mutational processes in human cancer (2013, neutral): “G mutations (9, 17), with others showing distinctive combinations of mutation classes (2, 13, 14).”
- Mechanisms of DNA damage, repair and mutagenesis (2017, positive): “In addition to the endogenous deamination sources, environmental exposure to UV radiation, intercalating agents, nitrous acid and sodium bisulfite can in general enhance base deamination rates in the DNA [Chen and Shaw, 1993; Moyer et al., 1993; Pfeifer et al., 2005; d’Ischia et al., 2011].”
- Exploiting the mutanome for tumor vaccination. (2012, background): “was C>T/G>A transitions, as often results from UV light (22).”
- UV Radiation and the Skin (2013, background): “UVB, for example, is a potent stimulator of inflammation and the formation of DNA photolesions (such as mutagenic thymine dimers) [112,113], whereas UVA is much less active in these measures but instead is a potent driver of oxidative free radical damage to DNA and other macromolecules [114–116].”
- Mutational Processes Molding the Genomes of 21 Breast Cancers (2012, background): “These occur at dipyrimidines, reflecting the formation of pyrimidine dimers following exposure of DNA to UV light (Pfeifer et al., 2005) and also show transcriptional strand bias due to the action of TCR on pyrimidine dimers.”