DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation.
By J. Cadet, J. Wagner. Cold Spring Harbor Perspectives in Biology, 2013
797 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/605171b34bd1c5bd15992b737045f615fa4578b6
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In Molecular Biology
Citations in the corpus
- Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases (2020, background): “Finally, ROS can damage DNA through oxidizing deoxyribose, breaking strand, removing nucleotides, modifying bases and crosslinking DNA-protein (Sharma et al., 2012; Cadet and Wagner, 2013; Cadet et al., 2017; Liang et al., 2020).”
- Arsenic Uptake, Toxicity, Detoxification, and Speciation in Plants: Physiological, Biochemical, and Molecular Aspects (2018, background): “Thus, the produced ROS can generate DNA–protein adducts and cause DNA and oxidative base damage [252], a break-up of chromatid/ chromosome or exchange [250], the formation of apyrimidinic/apurinic sites [253], DNA– protein cross-links [254], chromosomal aberrations, sister chromatid exchange, micron”