Th17 cytokines interleukin (IL)‐17 and IL‐22 modulate distinct inflammatory and keratinocyte‐response pathways
By K. Nograles, Lisa C. Zaba, E. Guttman‐Yassky, J. Fuentes-Duculan, M. Suárez‐Fariñas, I. Cardinale, A. Khatcherian, J. Gonzalez, K. C. Pierson, T. White and 5 more. British Journal of Dermatology, 2008
861 citations recorded by the source corpus.
Subfields: Dermatology, Immunology, Rheumatology
View Paper: https://www.semanticscholar.org/paper/5c8098a68806809d14d67f283870d54c3d539eaa
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Citations in the corpus
- Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis. (2011, methodology): “This is surprising given that IL-17 regulates only a small list of 35–40 genes in human KCs (Nograles et al., 2008) and human epidermal KCs are the dominant skin cell population expressing the IL-17 receptor, which exerts potent proinflammatory effects (Albanesi et al.”
- Progressive activation of Th2/Th22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis (2012, methodology): “%] in chronic AD skin) are within the psoriasis field, with few exceptions, including S100A7 and S100A8, which are synergistically induced by IL-17 and IL-22.”
- Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. (2010, background): “The range of inflammatory molecules produced in psoriasis lesions is also strongly regulated by Th1 and Th17 T cells, as interferong, IL-17, and IL-22 each induce a characteristic array of inflammatory products in KCs and other cell types present in psoriasis skin lesions (Nograles et al., 2008).”
- Immunology of Psoriasis (2014, background): “IFN-γ can induce CXCL10 and CXCL11 in keratinocytes, leading to recruitment of Th1 cells, while also increasing synthesis of Mx-1 and other antiviral gene products in keratinocytes (12).”