Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles.

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The nanosilica hazard: another variable entity (2010, background): “found in these studies with nanosilica [159-161], Lu et al.”
Zinc Oxide Nanoparticles for Selective Destruction of Tumor Cells and Potential for Drug Delivery Applications (2010, background): “All three of these levels have been observed for ZnO nanoparticles in immortalized phagocytic or bronchial epithelial cells, leading to damage of lipids, proteins and DNA, increased release of lactate dehydrogenase, and death by either necrosis or apoptosis [2,12,37,42,43].”
NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. (2009, background): “Silica nanoparticles Silica induces inflammatory (NF-kB activation) and oxidative stress responses both in vivo and in vitro [9,82,83], but cytotoxicity is largely only observed at high concentrations [84,85].”
Better safe than sorry: Understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications. (2010, background): “Furthermore, recent studies have indicated a lack of correlation between in vivo and in vitro effects of TiO2 nanoparticles [87].”
Magnetic nanoparticles for theragnostics (2009, result): “Direct comparison of in vivo and in vitro pulmonary nanotoxicity using the same assays showed little correlation [141], as NP Shubayev et al.”