Characterization and Enrichment of Cardiomyocytes Derived From Human Embryonic Stem Cells

By Chunhui Xu, Shailaja Police, Namitha Rao, M. Carpenter. Circulation Research, 2002

943 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5b11057670ddd12789ab9d0bf10b7e7bb76ce9f0

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Citations in the corpus

Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, background): “The cardiac-specific gene expression pattern, electrophysiological properties, and chronotropic responses to adrenergic and muscarinic agonists are also typical of cardiomyocytes (188, 239, 240, 402).”
Structural and Functional Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells (2013, result): “In agreement with previously published reports [9,10,33], early-stage hESC-CMs demonstrated poor subcellular organization and structural alignment, weak contractile performance, and relatively slow calcium release and reuptake kinetics.”
Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. (2008, methodology): “Catecholamines enhance cardiomyocyte beating rate and contractility (He et al., 2003; Xu et al., 2002), indicating the presence of intact adrenergic signal transduction pathways and a functional sarcoplasmic reticulum that regulates contraction through calcium-induced calcium ion release (Liu et al.”
Unchain my heart: the scientific foundations of cardiac repair. (2005, background): “The formation of functional cardiomyocytes by mouse and human embryonic stem cells is proven according to many criteria (83, 84).”
Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts (2007, background): “hES cells are an attractive population for cardiac repair because they can be isolated and maintained by well-established protocols, can be greatly expanded in culture and can be differentiated into definitive cardiomyocyte”
Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation (2005, background): “The ability of hESCs to differentiate spontaneously has been well documented (Itskovitz-Eldor et al., 2000; Reubinoff et al., 2000; Schuldiner et al., 2000; Levenberg et al., 2002; Xu et al., 2002).”