Exosome-Mediated Recognition and Degradation of mRNAs Lacking a Termination Codon

By A. van Hoof, P. Frischmeyer, H. Dietz, R. Parker. Science, 2002

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P-bodies and stress granules: possible roles in the control of translation and mRNA degradation. (2012, background): “Another mechanism of mRNA quality control is the rapid 30 to 50 degradation of mRNAs that do not contain translation termination codons, which is referred to as non-stop decay (NSD) (Frischmeyer et al. 2002; van Hoof et al. 2002).”
Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. (2007, background): “For one, while the 3 -to-5 pathway of NSD requires both N- and C-terminal domains of Ski7, decay following ribozyme-mediated cleavage, like the decay of normal mRNAs, does not require the C-terminal domain of Ski7 (Araki et al. 2001; van Hoof et al. 2002; Meaux and Van Hoof 2006).”
RNA-quality control by the exosome (2006, background): “, whereas the non-stop decay pathway degrades mRNAs that lack a termination codon altogethe”
Cytoplasmic foci are sites of mRNA decay in human cells (2004, background): “Thus, NMD, NSD, and 3 � ‐5 � NMD allow the removal of aberrant mRNAs and unspliced pre-mRNAs in the cytoplasm that could be deleterious to the cell (He et al., 1993; Frischmeyer et al., 2002; van Hoof et al., 2002 ).”