Comprehensive Epitope Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses Directed against the Entire Expressed HIV-1 Genome Demonstrate Broadly Directed Responses, but…

By M. Addo, Xu G. Yu, Almas Rathod, Daniel E. Cohen, Robert L. Eldridge, D. Strick, M. Johnston, C. Corcoran, A. Wurcel, Cecily A. Fitzpatrick and 10 more. Journal of Virology, 2003

759 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Virology

View Paper: https://www.semanticscholar.org/paper/7e05e7bb6e0b0cad35160f3df071d0f68c52e2e1

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The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Mario Roederer
2. Daniel C. Douek
3. R. Koup
4. A. Haase
5. A. McMichael

In Molecular Biology

1. Mario Roederer
2. M. Bunce
3. A. Prendergast
4. A. Khoruts
5. David E. Heckerman
6. Edward C. Holmes
7. A. McMichael
8. David S. Wishart

In Virology

1. Daniel C. Douek
2. Mario Roederer
3. R. Koup
4. A. Haase
5. Edward C. Holmes

Citations in the corpus

• The immune response during acute HIV-1 infection: clues for vaccine development (2009, background): “In contrast to the earliest stages of HIV-1 infection when the range of epitopes recognized by the T cell response is narrow, the later response is broad, often directed against more than 10 epitope”
• Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA (2004, result): “Previous studies have validated this approach, and have shown that the responses detected by this method are, with few exceptions, the result of CD8 p T-cell activit”
• Emerging Concepts in the Immunopathogenesis of AIDS (2009, background): “A number of studies demonstrate that the magnitude of the CD8 T cell response to HIV does not correlate with or predict progression (62, 63).”
• HIV evolution: CTL escape mutation and reversion after transmission (2004, background): “We focused here on the Gag polyprotein, as this is a highly immunogenic region of HIV-1 (refs”
• CD4+ T Cell Depletion during all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract (2004, background): “These epitopes were selected because they are frequently immunodominant and encompass the majority of HIV-specific CD8 T cells (40, 41).”
• CD8+ T-cell responses to different HIV proteins have discordant associations with viral load (2007, methodology): “For each individual, recognition by peripheral blood mononuclear cells (PBMC) of a panel of 410 overlapping 18-mer peptides spanning the entire C-clade consensus sequence was assessed in interferon (IFN)-γ enzyme-linked immunosorbent spot (ELISPOT) assays that preferentially detect CD8 + T-cell res”