OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity

By R. Strotmann, C. Harteneck, Karin Nunnenmacher, G. Schultz, T. Plant. Nature Cell Biology, 2000

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Trp ion channels and temperature sensation. (2006, background): “TRPV4, originally identified as an osmosensory ion channel, is also activated by warm temperatures (25 • C–34 • C) (Guler et al. 2002, Liedtke et al. 2000, Strotmann et al. 2000, Watanabe et al. 2002).”
Cellular and Molecular Mechanisms of Pain (2009, neutral): “When heterologously expressed, both TRPV2 and TRPV4 have been shown to respond to changes in osmotic pressure (Guler et al., 2002; Liedtke et al., 2000; Mochizuki et al., 2009; Strotmann et al., 2000).”
TRP Channels (2012, neutral): “Pore properties TRPV4 is a moderate Ca2+ selective cation channel with a PCa2+/PNa+ = 6-10 (390, 452, 470).”
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. (2003, background): “TRPV4, originally described as an osmo-sensor, has also been WC1E 6BN United Kingdom shown to be activated by warm temperatures (Guler et al., 2002; Liedtke et al., 2000; Strotmann et al., 2000).”
TRP channel proteins and signal transduction. (2002, background): “OTRPC4 (now designated TRPV3) has structural similarity to VR1, osm-9, and ECaC, and it is expressed in kidney, heart, and liver (177).”