Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma

By D. Kuperman, Xiaozhu Huang, L. Koth, G. Chang, G. Dolganov, Zhou Zhu, J. Elias, D. Sheppard, D. Erle. Nature Medicine, 2002

970 citations recorded by the source corpus.

Subfields: Immunology, Physiology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/5a299993113bf7a92c5129ceadc9b44e28ae1fa9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. H. Hammad
2. B. Lambrecht
3. P. Barnes
4. S. V. Van Dyken
5. J. Voynow
6. M. Rose
7. R. Locksley

In Physiology

1. H. Hammad
2. B. Lambrecht
3. P. Barnes
4. J. Voynow
5. M. Rose
6. R. Locksley

In Pulmonary and Respiratory Medicine

1. P. Barnes
2. J. Voynow
3. M. Rose
4. A. Varki

Citations in the corpus

• Mechanisms of fibrosis: therapeutic translation for fibrotic disease (2012, neutral): “However, other studies have suggested that IL-13 can promote fibrosis independently of TGF-β 85,86 by directly activating the synthetic and proliferative properties of fibroblasts, epithelial cells and smooth-muscle cells 87,88 .”
• The cytokine network in asthma and chronic obstructive pulmonary disease. (2008, background): “activating STAT6 in the airway epithelium (10), which increases”
• Respiratory tract mucin genes and mucin glycoproteins in health and disease. (2006, background): “The epithelium reverts nearly to baseline levels 11 days after multiple challenges with OVA (22) and GCM, which is maximal at 3 days after a single OVA exposure, is minimal 8 days following OVA exposure (239).”
• INTERLEUKIN-4- AND INTERLEUKIN-13-MEDIATED ALTERNATIVELY ACTIVATED MACROPHAGES: ROLES IN HOMEOSTASIS AND DISEASE (2013, positive): “For instance, transgenic expression of hSTAT6 in CC10-expressing epithelial cells restores IL-13-induced mucus overproduction and AHR in STAT6-deficient mice (162).”
• Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma (2008, background): “Indeed many of the features of asthma, such as bronchial hyper-reactivity and goblet-cell hyperplasia, can be mimicked by administration of IL-13, which acts on epithelial cells and/or DCs in a signal transducer and activator of transcription 6 (STAT6)-dependent manne”
• Interleukin‐13 in asthma pathogenesis (2004, background): “(86) provide strong support for a central role of the airway epithelium in IL-13-induced AHR and mucus hypersecretion.”