Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney

By M. Takasato, Pei Xuan Er, M. Becroft, J. Vanslambrouck, E. Stanley, A. Elefanty, M. Little. Nature Cell Biology, 2013

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Nephron organoids derived from human pluripotent stem cells model kidney development and injury (2015, positive): “A key difference between our protocol and previous ones 17,18 is our strategy to induce late-stage mid primitive streak rather than posterior primitive streak, based on developmental studies showing that the posterior primitive streak gives rise to lateral plate mesoderm rather than IM 24–26 .”
Organogenesis in a dish: Modeling development and disease using organoid technologies (2014, background): “Skeletal muscle Embryonic chick leg skeletal muscle (76) Mesoangioblasts from human iPSCs (106) Anchored contracting skeletal muscle in 3D matrix derived from myoblast progenitors (107) Bone Skeletal bone of chick embryonic leg (77) Osteoblasts from mESCs (108) and hESCs (109) Bone spheroids from hu”
Stem Cell Organoid Engineering (2016, positive): “…3D scaffold and biochemical factors, differentiated cells from PSCs will self-organize to form tissue-specific organoids including the optic cup (Eiraku et al., 2011), brain (Lancaster et al., 2013), intestine (Spence et al., 2011), liver (Takebe et al., 2013), and kidney (Takasato et al., 2014).”
Modeling Development and Disease with Organoids. (2016, background): “Little and colleagues managed to balance the two divergent commitment paths to produce both principal lineages of the kidney simultaneously (Takasato et al., 2014).”