Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

By Yukihiro Furusawa, Yuuki Obata, S. Fukuda, T. Endo, G. Nakato, D. Takahashi, Yumiko Nakanishi, Chikako Uetake, Keiko Kato, Tamotsu Kato and 20 more. Nature, 2013

4,885 citations recorded by the source corpus.

Subfields: Food Science, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5a0a2f5f18cac535b183c35f839e01c064df9308

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In Food Science

1. M. Zeng
2. G. Núñez
3. A. Valdes
4. Ana Nogal
5. Lan Lin
6. Chang H. Kim
7. Justin L. Sonnenburg
8. C. Menni

In Infectious Diseases

1. Justin L. Sonnenburg
2. T. Kanai
3. K. Matsuoka
4. E. Sonnenburg
5. Y. Belkaid
6. O. Harrison
7. M. Zeng
8. J. Cryan

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. C. Stanton
5. R. Stilling
6. F. Bäckhed
7. Justin L. Sonnenburg
8. E. Sonnenburg

Citations in the corpus

• The gut microbiome: Relationships with disease and opportunities for therapy (2018, background): “Regulation of colonic T reg cell homeostasis (Furusawa et al., 2013; Smith et al., 2013)”
• Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study (2016, background): “reported that microbial-derived butyrate regulates Treg cell differentiation in vitro and in vivo [27].”
• Free Fatty Acid Receptors in Health and Disease. (2020, background): “In addition, butyrate induces the differentiation of regulatory T cells in vitro and in vivo and ameliorated the development of colitis induced by adoptive transfer of CD4 CD45RB T cells in RAG1deficient mice (94).”
• Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans (2017, background): “Butyrate is a primary fuel source for colonocytes (39), is required for maintaining gut barrier function (40), and is a critical metabolite regulating the antiinflammatory/regulatory phenotypes of gut-resident immune cells (41).”
• Short-chain fatty acids: linking diet, the microbiome and immunity (2024, positive): “By increasing histone acetylation and increasing the amount of open chromatin, butyrate impacts gene expression in intestinal epithelial cells, macrophages, DCs and lymphocytes, particularly T reg cells 51–53 .”
• Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine. (2015, positive): “expansion of intestinal T regulatory (Treg) cells (Smith et al., 2013; Furusawa et al., 2013), andmicrobiome analyses of a large cohort of affected individuals with type 2 diabetes revealed a lack of butyrate-producing bacteria, further underscoring the impact of FAs in health and disease (Qin et al”
• Gut Microbiota and Immune System Interactions (2020, background): “Butyrate also modulates the differentiation of anti-inflammatory forkhead box protein P3 (Foxp3), which has an essential role in the suppression of inflammatory responses [14,15].”