salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines.

By N. Tapon, K. Harvey, D. Bell, D. Wahrer, T. Schiripo, D. Haber, I. Hariharan. Cell, 2002

884 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/59f34e780004fb39c00e2bc3cc82a85c674b6827

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In Cell Biology

1. K. Guan
2. Duojia Pan
3. Bin Zhao
4. G. Halder
5. Fa-Xing Yu
6. S. Piccolo
7. Randy L. Johnson
8. M. Cordenonsi

In Molecular Biology

1. K. Guan
2. Duojia Pan
3. Bin Zhao
4. G. Halder
5. Fa-Xing Yu
6. Randy L. Johnson
7. S. Piccolo
8. Xaralabos Varelas

Citations in the corpus

• Drosophila orthologues to human disease genes: an update on progress. (2008, background): “The human orthologue of salvador (hWW45) is also mutated in cancer cell lines (59).”
• The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. (2010, background): “sav (shar-pei) encoding a WW domain-containing protein and hippo (hpo) encoding a STE20 family protein kinase are two other Hippo pathway components identified in a similar fashion to that of wts (Kango-Singh et al. 2002; Tapon et al. 2002; Harvey et al. 2003; Jia et al. 2003; Pantalacci et al. 2003”
• Hippo signaling in organ size control. (2007, background): “For example, mice lacking a wts homolog develop soft-tissue sarcomas and ovarian tumors (St John et al. 1999), and the human orthologs of sav and mats are mutated in several cancer cell lines (Tapon et al. 2002; Lai et al. 2005).”
• TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway (2008, background): “Many components in the Hippo pathway, including Mer, Lats, and Sav, have been implicated as tumor suppressor genes (14, 19, 28, 29, 31).”
• The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. (2005, methodology): “Studies from several groups, including our own, have suggested that these genes function in a common pathway that coordinately regulates cell proliferation and apoptosis by targeting the cell-cycle regulator CycE and the celldeath inhibitor DIAP1 (Tapon et al., 2002; Kango-Singh et al., 2002; Harvey”
• Mechanisms and pathways of growth failure in primordial dwarfism. (2011, background): “2002), the growth-promoting microRNA bantam (Thompson and Cohen 2006), and the anti-apoptotic protein dIAP (Drosophila inhibitor of apoptosis) (Tapon et al. 2002).”
• The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease (2014, background): “The Hippo pathway was identified in genetic studies of Drosophila melanogaster as a suppressor of tissue overgrowth (Huang et al., 2005; Jia et al., 2003; Justice et al., 1995; Pantalacci et al., 2003; Tapon et al., 2002; Udan et al., 2003; Wu et al., 2003).”
• The Hippo Signaling Pathway in Development and Cancer (2010, background): “Deletion of WW45 was reported in two renal cancer cell lines (Tapon et al., 2002), and mutations in Mob1 were found in two cDNAs derived from a human melanoma and a mouse mammary carcinoma, respectively (Lai et al.”
• A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). (2010, background): “Regulation of YAP/ Yki activity was first revealed by genetic studies of the Hippo tumor suppressor pathway in Drosophila (KangoSingh et al. 2002; Tapon et al. 2002; Harvey et al. 2003; Jia et al. 2003; Pantalacci et al. 2003; Udan et al. 2003; S Wu et al. 2003; Lai et al. 2005).”
• YAP/TAZ at the roots of cancer (2016, background): “In fact, Hippo pathway components were originally discovered in the fly before Yorkie, by means of genetic screens aimed at isolating genes regulating the growth of larval tissues (Harvey et al., 2003; Justice et al., 1995; Tapon et al., 2002; Wu et al., 2003; Xu et al., 1995; reviewed in Pan, 2010)”
• The Hippo pathway: regulators and regulations. (2013, background): “…Mob all lead to significant tissue outgrowth, as indicated by enlarged eyes, wings, or other appendages (Justice et al. 1995; Xu et al. 1995; Kango-Singh et al. 2002; Tapon et al. 2002; Harvey et al. 2003; Jia et al. 2003; Pantalacci et al. 2003; Udan et al. 2003; Wu et al. 2003; Lai et al. 2005).”