Regeneration beyond the glial scar

By J. Silver, Jared H. Miller. Nature Reviews Neuroscience, 2004

3,077 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/59d5a3a354ec406bb2893f41226909589b20a3c6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. M. Sofroniew
2. B. Barres
3. M. Pekny
4. S. Carmichael
5. M. Pekna
6. J. Silver
7. Dale Corbett
8. J. Joyce

In Cellular and Molecular Neuroscience

1. M. Sofroniew
2. M. Pekny
3. M. Pekna
4. H. Vinters
5. S. Carmichael
6. E. Hol
7. Y. Ao
8. B. Song

Citations in the corpus

• Glial inhibition of CNS axon regeneration (2006, background): “In addition, reactive astrocytes form a glial scar at the lesion site and might act as an additional barrier to axon regrowt”
• Astrocytes: biology and pathology (2009, background): “Severe reactive astrogliosis and glial scar formation at sites of CNS trauma are well documented to inhibit axonal regeneration [219] and are widely regarded as detrimental to clinical outcome.”
• cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury (2004, background): “The injured adult mammalian CNS is an environment that does not support regrowth of damaged axons, in part because of an abundance of growth-inhibitory molecules in myelin and the glial sca”
• The biophysics of neuronal growth (2010, neutral): “regrowth of axons [240, 241].”
• Origin of new glial cells in intact and injured adult spinal cord. (2010, background): “Astrocytes are the dominating glial cells in the scar that forms at the injury, and chondrotin sulfate proteoglycans in the scar inhibit axonal regrowth, indicating that astrocytes prevent axonal regeneration (Busch and Silver, 2007; Silver and Miller, 2004).”
• Activated Microglia Contribute to the Maintenance of Chronic Pain after Spinal Cord Injury (2006, background): “Reactive astrogliosis is known to participate in scar formation and genesis of a regenerative barrier after SCI ( Silver and Miller , 2004 ) , the elimination of which can lead to improvements in neuromotor function ( Menet et al .”
• The tumor microenvironment underlies acquired resistance to CSF1R inhibition in gliomas (2016, result): “Given that IL4 is a known mediator of alternative activation associated with a wound-healing phenotype in macrophages (20, 29), and the role of TGFb1 during wound-healing and tissue turnover in multiple contexts (30, 31), these results were consistent with our observation of glial scarring in associ”
• The Biology of Regeneration Failure and Success After Spinal Cord Injury. (2018, background): “For example, in the vicinity of the glial scar, neurites attempting to regrow will come into contact with gradually increasing concentrations of CSPGs as they struggle within the lesion epicenter (350).”
• A microfluidic culture platform for CNS axonal injury, regeneration and transport (2005, background): “Cocultures with other cell types, such as oligodendrocytes or astrocytes will also help to investigate mechanisms of axonal injury and regeneratio”
• Astrocytes: a central element in neurological diseases (2016, background): “Accordingly, recent critical reviews call for alternative concepts to identify new targets for improved therapeutic approaches [65, 138, 205].”