Intracellular pattern recognition receptors in the host response

By E. Meylan, J. Tschopp, M. Karin. Nature, 2006

1,253 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5988d3a3268cb3c8ab2597e2a112675b52da2501

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Shizuo Akira
2. J. Tschopp
3. O. Takeuchi
4. T. Mogensen
5. G. Núñez
6. E. Latz
7. Katherine A. Fitzgerald
8. H. Kono

In Molecular Biology

1. J. Tschopp
2. G. Núñez
3. E. Latz
4. Shizuo Akira
5. Katherine A. Fitzgerald
6. O. Takeuchi
7. T. Mogensen
8. T. Kanneganti

Citations in the corpus

• Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation (2007, background): “Some NLRs are involved in the recognition of microbial molecules that are introduced by pathogens and/or endogenous factors released from tissues undergoing destructio”
• Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “These danger signals originate from host molecules with aberrant locations, structures, or interactions induced by, e.g., necrosis or oxidative damage of cells or tissues, as exemplified by uric acid, ATP, potassium, hyaluronan fragments, and HSPs (146, 236, 247, 362, 365).”
• Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists (2007, neutral): “Innate immune recognition relies on a diverse set of germ line–encoded receptors, termed pattern recognition receptors (PRR), which recognize broad classes of molecular structures common to groups of microorganism”
• The perfect mix: recent progress in adjuvant research (2007, background): “Such cytosolic sensors include NODs (nucleotide-binding oligomerization domain proteins), NOD-like receptors (NLRs) and RIG-like helicases (RLHs), which sense signals from intracellular bacteria and viruses, respectivel”
• Type 1 diabetes: etiology, immunology, and therapeutic strategies. (2011, neutral): “cytoplasmic sensor for viral infection (221, 291).”
• MDA5/RIG-I and virus recognition. (2008, background): “Introduction Innate immunity is characterized by the use of germlineencoded pattern recognition receptors (PRRs) to sense components specific to micro-organisms [1–3].”
• Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry (2010, background): “The recognition of pathogens by the innate immune system relies on the detection of motifs that are highly conserved among pathogens, called pathogen-associated molecular patterns, by germline-encoded pattern-recognition molecule”
• Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by RIG-I (2009, background): “To elicit IFN responses, mammalian hosts have evolved a variety of cellular pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs), which sense the presence of viral nucleic acids or other conserved molecular components of invading microbes (Akira e”