Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo.

By John R. Cirrito, Jae-Eun Kang, Jiyeon Lee, F. Stewart, D. Verges, L. M. Silverio, G. Bu, S. Mennerick, D. Holtzman. Neuron, 2008

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How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Activity-driven local ATP synthesis is required for synaptic function (2014, neutral): “Interestingly, endocytic machinery have recently been linked to amyloidbeta pathology (Cirrito et al., 2008), suggesting its potential link with mitochondrial dysfunction.”
Amyloid Precursor Protein Processing and Alzheimer’s Disease (2011, background): “Combined with data showing that synaptic activity regulates Aβ production in neurons (Cirrito et al. 2008), there is powerful incentive for future work in this area.”
The Role of Apolipoprotein E in Alzheimer’s Disease (2009, neutral): “The majority of extracellular Aβ is generated through the endocytosis of APP into the endocytic compartment, where both secretases can optimally produce A (Cirrito et al., 2008; Koo and Squazzo, 1994).”
Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer’s Disease (2009, background): “A model system that can measure activity and metabolic influences on AD pathology will be necessary to test these hypotheses fully (Cirrito et al., 2005, 2008).”
Trafficking and proteolytic processing of APP. (2012, background): “2005) and inhibition of endocytosis (Cirrito et al. 2008) each reduce ISF Ab levels, there remained the question of the extent as to which (or both) contributes to ISF Ab levels.”