The parkinson's complex: Parkinsonism is just the tip of the iceberg

By J. Langston. Annals of Neurology, 2006

601 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/59281c3da77b65f5f445cf155ef4e5128f30ba0a

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Citations in the corpus

Parkinson's disease: a dual‐hit hypothesis (2007, background): “Furthermore, any speculation regarding the cause and beginnings of PD must take into account the involvement of olfactory and autonomic systems that generally develop prior to the onset of the classical somatomotor symptoms [26] [27] [28] .”
Genetic Animal Models of Parkinson’s Disease (2010, unknown): “Moreover, there are numerous clinical features of PD that are not attributable to the degeneration of DA neurons (Langston, 2006).”
Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders (2010, unknown): “A critical question has been whether or not a-synuclein histopathology begins in the brain or within elements of the peripheral nervous system [20, 38, 55].”
Parkinson's disease and parkinsonism: neuropathology. (2012, background): “…dysfunction is common in PD and that it may also be an early feature of the disease, given recent evidence that peripheral nerves and ganglia of the autonomic nervous system are affected early in PD and may actually be affected prior to significant brain involvement (Langston 2006; Lang 2007).”
The Parkinson Progression Marker Initiative (PPMI). (2011, background): “Even when the study subjects are enrolled early in disease, substantial neurodegeneration has already occurred (Braak and Del Tredici, 2008; Eckert et al., 2007; Fearnley and Lees, 1990; Langston, 2006; Marek and Jennings, 2009).”
Parkinson's disease: genetics and pathogenesis. (2011, background): “Motor features remain the essential criteria for clinical diagnosis of PD and are a major source of disability, but PD has a much broader impact on the nervous system (9, 10).”
Parkinson disease: from pathology to molecular disease mechanisms. (2013, background): “Although this has been the classical textbook description of PD, more recently it has become recognized as a more complex illness encompassing both motor and nonmotor symptoms (NMS), such as depression, sleep disturbance, sensory abnormalities, autonomic dysfunction, and cognitive decline [74].”
Missing pieces in the Parkinson's disease puzzle (2010, background): “Onset and progression—clinical questions Is Parkinson's disease a single disorder? The traditional view of Parkinson's disease as a single clinical entity is under scrutin”