Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

By T. Beach, C. Adler, L. Sue, Linda J. Vedders, L. Lue, Charles L. White, H. Akiyama, J. Caviness, H. Shill, M. Sabbagh and 1 more. Acta Neuropathologica, 2010

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A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, including 23 normal elderly, 7 with incidental Lewy body disease (ILBD), 17 with Parkinson’s disease (PD), 9 with dementia with Lewy bodies (DLB), 19 with Alzheimer’s disease with Lewy bodies (ADLB) and 17 with Alzheimer’s disease with no Lewy bodies (ADNLB). The relative densities and frequencies of occurrence of phosphorylated α-synuclein histopathology (PASH) were tabulated and correlated with diagnostic category. The greatest densities and frequencies of PASH occurred in the spinal cord, followed by the paraspinal sympathetic ganglia, the vagus nerve, the gastrointestinal tract and endocrine organs. The frequency of PASH within other organs and tissue types was much lower. Spinal cord and peripheral PASH was most common in subjects with PD and DLB, where it appears likely that it is universally widespread. Subjects with ILBD had lesser densities of PASH within all regions, but had frequent involvement of the spinal cord and paraspinal sympathetic ganglia, with less-frequent involvement of end-organs. Subjects with ADLB had infrequent involvement of the spinal cord and paraspinal sympathetic ganglia with rare involvement of end-organs. Within the gastrointestinal tract, there was a rostrocaudal gradient of decreasing PASH frequency and density, with the lower esophagus and submandibular gland having the greatest involvement and the colon and rectum the lowest.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/0c85215a9d7886d4239e4e7c527f1d2f0f9955c2

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Citations in the corpus

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice (2012, background): “…established presence of Syn pathology in olfactory and enteric neurons in PD (Wakabayashi et al., 1989; Daniel and Hawkes, 1992; Duda et al., 1999; Beach et al., 2010), there is currently no di rect evidence that PD or DLB are either infectious or acquired from an external source via nasal or…”
Past, Present, and Future of Parkinson’s Disease: A Special Essay on the 200th Anniversary of the Shaking Palsy (2017, positive): “9 in 2 population-based studies).(222) It may also have high sensitivity, because even in early PD, >80% of patients have some measurable hyposmia.”
Parkinson's disease and parkinsonism: neuropathology. (2012, background): “The subthalamic nucleus and the superior cerebellar peduncle are not affected in PD or MSA.”