Control of B-cell responses by Toll-like receptors

By Chandrashekhar Pasare, R. Medzhitov. Nature, 2005

814 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/583f63390638244f3d009ffd76144e366a40cfc8

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In Immunology

Citations in the corpus

NF-κB and the immune response (2006, background): “Recently, it has been suggested that TLR signaling in B cells is also required for optimal response to certain antigens (Pasare and Medzhitov, 2005).”
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling (2020, background): “The initiation of the adaptive immune responses follows activation of various TLRs and involves antigen presentation in the context of major histocompatibility complex (MHC) class I and II, as reviewed by [5, 117].”
Pattern recognition receptors and control of adaptive immunity (2009, background): “TLRs can also control B-cell responses to T-dependent and T-independent antigens (21, 27, 28), as well as self-antigens (29).”
The perfect mix: recent progress in adjuvant research (2007, background): “Moreover, direct TLR stimulation is also needed to fully activate B cell”
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “TLRs may also play a role in mechanisms of immune suppression by regulatory T lymphocytes and in humoral immune responses mediated by B lymphocytes (48, 289, 290).”
AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity1 (2009, result): “Recent studies clearly indicate that, contrary to murine B cells (47), human purified B cells do not express TLR4 and are not able to respond to LPS stimulation, even during concomitant BCR stimulation.”