Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines.

By David M. Brown, M. Wilson, W. Macnee, Vicki Stone, Ken Donaldson. Toxicology and Applied Pharmacology, 2001

1,274 citations recorded by the source corpus.

Subfields: Health, Toxicology and Mutagenesis, Speech and Hearing

View Paper: https://www.semanticscholar.org/paper/58360e545b4b308ecdb8f157669db7a5d168f284

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Health, Toxicology and Mutagenesis

In Speech and Hearing

Citations in the corpus

NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. (2009, background): “Consequently, the smaller the nanoparticle, the higher the oxidative stress they induce [24,25].”
Microplastic moves pollutants and additives to worms, reducing functions linked to health and biodiversity. (2013, positive): “Because mammalian cells exposed to nanometer-sized plastic also produce reactive oxygen species and less protein [35, 40], we suggest that the smaller capacity of worms to deal with oxidative stress could be indicative of proteolysis or reductions in synthesis of their antioxidants.”
Nanoparticle exposure at nanotechnology workplaces: A review (2011, background): “[57] and stressed by several other researchers [58,59].”
Biocompatibility of engineered nanoparticles for drug delivery. (2013, background): “A number of studies have reported that the response of biological systems to nanoparticles is specific to its surface properties rather than its mass [26–30].”
In vitro toxicity of silica nanoparticles in human lung cancer cells. (2006, background): “For instance, differential toxicity between micro- and nanoscale materials has been observed in TiO2 particles (Oberdörster, 2000), polystyrene particles (Brown et al., 2001), andmineral fibers (Donaldson and Tran, 2002).”
Exposure to Carbon Nanotube Material: Assessment of Nanotube Cytotoxicity using Human Keratinocyte Cells (2003, background): “It has been speculated that nanometer-sized particles may be more toxic than larger ones due to their increased surface area (Brown et al., 2001) and size-dependent modifications to surface properties (Preining, 1998; Jefferson, 2000).”
Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy (2005, background): “The large surface area of nanoparticles means that they can adsorb proteins [152,153].”
Assessing exposure to airborne nanomaterials: Current abilities and future requirements (2007, background): “(Lison et al. 1997; Oberdörster 2000; Tran et al. 2000; Brown et al. 2001).”
Airborne Particulate Matter and Human Health: Toxicological Assessment and Importance of Size and Composition of Particles for Oxidative Damage and Carcinogenic Mechanisms (2008, background): “During a pollution episode, each lung acinus could receive on average 30-million particles and each alveolus about 1500 particles (for 24 h exposure) of which 50% are being deposited ( 72 ).”