Astrocytes potentiate transmitter release at single hippocampal synapses

By Araque Alfonso. 2009

625 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/5722dae4a0c16a41ded936d51a478101e50ef662

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. L. Mucke
2. J. Palop
3. Beth Stevens
4. David Holcman
5. Marie-Eve Tremblay
6. H. Wake
7. A. Bessis
8. Amanda Sierra

In Developmental Neuroscience

1. Beth Stevens
2. David Holcman
3. Marie-Eve Tremblay
4. H. Wake
5. A. Bessis
6. L. Mucke
7. Amanda Sierra
8. A. Nimmerjahn

In Neurology

1. Beth Stevens
2. Marie-Eve Tremblay
3. H. Wake
4. A. Bessis
5. L. Mucke
6. Amanda Sierra
7. A. Nimmerjahn
8. J. Palop

Citations in the corpus

• The Role of Microglia in the Healthy Brain (2011, methodology): “, 2008), which binds to neuronal receptors such as mGluR receptors to modulate AMPAergic synapses (Fiacco and McCarthy, 2004; Perea and Araque, 2007), we applied the mGluR5 antagonist MPEP.”
• Physiology of Astroglia. (2018, neutral): “Astroglial release of glutamate, for example, has been shown to result in 1) inhibition of evoked and spontaneous excitatory or inhibitory postsynaptic currents (EPSCs or IPSCs) in hippocampus (57, 992); 2) potentiation of spontaneous excitatory postsynaptic currents (EPSCs) or inhibitory postsynapt”
• Astroglial networks: a step further in neuroglial and gliovascular interactions (2010, background): “Interestingly, at the level of the single cell and in the particular context of the tripartite synapse, astrocytes are thought to boost neuronal activity by releasing glutamat”
• Long term potentiation depends on release of D-serine from astrocytes (2010, neutral): “The importance of D-serine for LTP does not exclude the potential role of astrocytic glutamate release6,8, and the precise mechanisms acting on the microscopic scale require further investigation.”
• Immune modulation of learning, memory, neural plasticity and neurogenesis. (2011, neutral): “In AD patients, acute or chronic systemic infections and the associated pro-inflammatory cytokine production was found to aggravate the AD symptoms (Perry, 2004).”
• Amyloid-β Induced Neuronal Dysfunction in Alzheimer’s Disease: From Synapses toward Neural Networks (2010, background): “Glutamate released from astrocytes can also act presynaptically on mGluRs, increasing the probability of transmitter release in glutamatergic terminal”
• Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission (2011, background): “In the CA1 region of the hippocampus, glutamate released by astrocytes facilitates the release of neurotransmitter by activation of group I mGluR presumably located on presynaptic neurons (6, 7).”