A perivascular origin for mesenchymal stem cells in multiple human organs.

By M. Crisan, Solomon V. Yap, L. Casteilla, Chien‐Wen Chen, M. Corselli, T. Park, G. Andriolo, Bin Sun, B. Zheng, Li Zhang and 11 more. Cell Stem Cell, 2008

3,966 citations recorded by the source corpus.

Subfields: Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/5696f0bc36fff47bddab6dfb000d3efca81c3572

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Jeremy N. Rich
2. J. Karp
3. A. Caplan
4. Grace Sock Leng Teo
5. R. Lee
6. Jaehyup Kim
7. P. Hematti
8. J. Lathia

In Surgery

1. J. Karp
2. A. Caplan
3. Grace Sock Leng Teo
4. R. Lee
5. Jaehyup Kim
6. P. Hematti
7. Michael A. Rudnicki
8. C. Gregory

Citations in the corpus

• The elusive nature and function of mesenchymal stem cells (2011, positive): “Long-term cultures derived from prospective pericytes isolated directly from these organs, based on specific expression of those markers, displayed similar morphological features to cultured mesenchymal stromal cells, as well as trilineage potential in vitro and osteogenic potential in vivo”
• Targeting cancer stem cell pathways for cancer therapy (2020, background): “Current studies hypothesize that there are five possible sources: (1) transference of fibroblasts in the host stroma; 471 (2) EMT; 472 (3) transdifferentiation of perivascular cells; 473 (4) EMT; 474 and (5) differentiation of MSCs derived from bone marrow.”
• Geometric cues for directing the differentiation of mesenchymal stem cells (2010, background): “M stem cells (MSCs) are multipotent cells that were initially isolated from bone marrow and noted for their ability to differentiate into bone cells (osteoblasts), cartilage cells (chondrocytes), and fat cells (adipocytes) (1, 2).”
• Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis (2014, neutral): “Vasculature represents the in vivo niche of MSCs, helping to explain why MSCs have such a broad tissue distribution (Crisan et al., 2008).”
• Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth (2013, positive): “Further, pericytes are similar to mesenchymal stem cells (MSCs) (Crisan et al., 2008).”
• Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine (2017, background): “All of these MCSs can be isolated and expanded from stroma of many tissues, the bone marrow and subcutaneous fat being the preferred sources [28].”
• Wound Healing: A Cellular Perspective. (2019, background): “Another hypothesis is that pericytes and mesenchymal stromal cells (MSCs) with multipotent regeneration capacity arise from the same pool of cells (73).”
• Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “However, whereas there is no doubt that MSCs can be isolated from perivascular locations in most—perhaps all—organs (Crisan et al., 2008b; Dellavalle et al., 2007; Tang et al., 2008), the question remains whether they are identical to the cells that a vascular biologist would refer to as pericytes.”
• All MSCs are pericytes? (2008, background): “This model is in keeping with the differentiation-focused discussion of Crisan et al. (2008).”
• Hallmarks of cancer: interactions with the tumor stroma. (2010, background): “Isolated pericytes from a range of normal tissues exhibit expression of hallmark proteins for mesenchymal stem cells and harbor the potential to differentiate into myogenic, osteogenic, chondrogenic, and adipogenic lineages [56].”
• Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate. (2014, background): “adhesions [57, 86], and the cytoskeleton [126] have been suggested.”
• Mesenchymal stem cell perspective: cell biology to clinical progress (2019, positive): “Further, although bone marrow was first used for MSC isolation and considered a renewable source, MSC-like cells have been isolated from many tissue sources including harvested adipose tissue,7,8 umbilical Wharton’s jelly,9 placenta,10,11 skin73 and the roots of shed teeth.74 The studies of microvas”
• Mesenchymal stem cell-educated macrophages: a novel type of alternatively activated macrophages (2009, background): “Cells with similar characteristics to BM-MSCs have been found in most human tissues examined [4-6], as well as other animals [7-9].”