Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women.

By Rudolf Kaaks, P. Toniolo, A. Akhmedkhanov, A. Lukanova, C. Biessy, H. Déchaud, S. Rinaldi, A. Zeleniuch-Jacquotte, R. Shore, E. Riboli. Journal of the National Cancer Institute, 2000

678 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Oncology

View Paper: https://www.semanticscholar.org/paper/56894b1083705e20d918112a9d1847d4b7e0babc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. S. Firth
2. B. Spiegelman
3. Michael Pollak

In Oncology

1. S. Larsson
2. E. Calle
3. B. Spiegelman
4. A. Wolk
5. Rudolf Kaaks
6. M. Woodward
7. R. Huxley
8. Ali G. Moghaddam

Citations in the corpus

• Cellular actions of the insulin-like growth factor binding proteins. (2002, background): “Increasing IGFBP-1 levels have been associated with a decrease in colorectal cancer risk (360), and in correlative studies, breast cancer patients have been shown in one study to have lower serum levels of IGFBP-1 and IGFBP-6 than women with benign breast disease (365).”
• Obesity and cancer risk: Emerging biological mechanisms and perspectives. (2019, background): “C-peptide levels have been associated with the risk of CRC in the New York University Women’s Health Study, and have been replicatedwithin the European Prospective Investigation into Cancer and Nutrition (EPIC) study [68,69].”
• Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms (2004, background): “In addition, prospective cohort studies have shown increased risks of cancers of the colon or of the colorectum among individuals with increased pre-diagnostic blood levels of C-peptide (a marker for pancreatic insulin secretion”
• Obesity and Risk of Colorectal Cancer: A Systematic Review of Prospective Studies (2013, background): “Discussion The present meta-analysis summarizes the results of prospective studies, including 41 studies [7,8,9,10,11,12,13,14,15,16,17,18, 19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39, 40,41,42,43,44,45,46,47] on BMI levels with a total of 85, 935 cases and including 13 studies [7”
• Energy balance and cancer: the role of insulin and insulin-like growth factor-I (2001, background): “In the long term, regular exercise (‘training’) may improve insulin sensitivity, also, through the prevention or reduction of excess body weight and obesity.”
• Molecular mechanisms of cancer development in obesity (2011, background): “Furthermore, reduced levels of IGFBP1 are associated with an increased risk of colorectal cance”
• Obesity and colon and rectal cancer risk: a meta-analysis of prospective studies. (2007, background): “Epidemiologic evidence indicates that high circulating concentrations of insulin and C-peptide (a marker of pancreatic insulin secretion) (24, 47–51) as well as diabetes (52) are associated with a greater risk of colorectal cancer.”