Drusen proteome analysis: An approach to the etiology of age-related macular degeneration

By J. Crabb, M. Miyagi, X. Gu, K. Shadrach, K. West, H. Sakaguchi, M. Kamei, A. Hasan, Lin Yan, M. Rayborn and 2 more. Proceedings of the National Academy of Sciences of the United States of America, 2002

1,255 citations recorded by the source corpus.

Subfields: Ophthalmology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/56777252bd03c9f9e59663891e03c8a458996b5f

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In Ophthalmology

1. O. Strauß
2. I. Bhutto
3. G. Lutty
4. M. Zarbin

In Radiology, Nuclear Medicine and Imaging

1. O. Strauß
2. M. Zarbin

Citations in the corpus

• Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex (2012, background): “N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript capillary pillars of the choroid (Crabb et al., 2002; Johnson et al., 2001; Johnson et al., 2000) and in the vitreous of human eyes.”
• Current concepts in the pathogenesis of age-related macular degeneration. (2004, background): “As noted in the “Bruch Membrane Thickness” subsection, mutations in TIMP-3 cause Sorsby fundus dystrophy, which is associated accumulation of abnormal extracellular material in the Bruch membrane, patchy choroidal filling on fluorescein angiography, and CNVs.”
• The Pivotal Role of the Complement System in Aging and Age-related Macular Degeneration: Hypothesis Re-visited (2009, neutral): “…proteins are molecular constituents of drusen, the hallmark extracellular deposits associated with early stage AMD (Anderson et al., 2002, 2004; Crabb et al., 2002; Hageman and Mullins, 1999; Hageman et al., 1999a; Johnson et al., 2002, 2001, 2000, 2003, 2006; Laine et al., 2007; Mullins et…”
• The retinal pigment epithelium in visual function. (2005, background): “However, a more detailed analysis of the protein composition of Drusen led to alternative theories of Drusen formation (128, 226, 519).”
• Para-inflammation in the aging retina. (2009, background): “…aging human Bruch’s membrane (Glenn et al., 2009; Handa et al., 1999) and in drusen of eyes with AMD (Hollyfield et al., 2003; Yamada et al., 2006). b-amyloid is also detected in drusen and is one of the main components of drusen (Anderson et al., 2004; Crabb et al., 2002; Mullins et al., 2000).”
• The Impact of Oxidative Stress and Inflammation on RPE Degeneration in Non-neovascular AMD (2017, background): “…contains multiple OSEs including MDA and 4-HNE adducts, as well as AGEs (Schutt et al., 2003; Schutt et al., 2002), while Bruch’s membrane, including drusen, contains AGEs, MDA, CEP, and oxidized phospholipids (OxPL) (Crabb et al., 2002; Farboud et al., 1999; Sun et al., 2005; Suzuki et al., 2007).”