The Nrf2 regulatory network provides an interface between redox and intermediary metabolism.

By J. Hayes, A. Dinkova-Kostova. TIBS -Trends in Biochemical Sciences. Regular ed, 2014

2,005 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/566609be74b15e76f846d22a92e21034007a37b4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. A. Dinkova-Kostova
2. Donna D. Zhang
3. J. Hayes
4. M. Kerins
5. Aikseng Ooi
6. A. Abramov
7. D. Tuveson
8. I. I. C. Chio

In Physiology

1. A. Dinkova-Kostova
2. Donna D. Zhang
3. A. Abramov
4. J. Hayes
5. K. Tew

Citations in the corpus

• Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease (2015, neutral): “In total, it regulates directly a battery of approximately 250 genes involved in a wide variety of cellular functions ranging from cytoprotection against endogenous and environmental stressors to lipid and carbohydrate metabolism [62].”
• The Roles of NRF2 in Modulating Cellular Iron Homeostasis (2017, background): “Excellent reviews encompassing the NRF2peroxiredoxin system are available (35, 39, 150, 174).”
• Oxidative Stress in Cancer (2020, background): “Because it regulates a wide spectrum of antioxidant and detoxification genes, NRF2 provides a principal inducible defense against oxidative stress (Hayes and Dinkova-Kostova, 2014; Sies et al., 2017), but whether it is more readily activated by ROS than other redox-responsive transcription factors i”
• NRF2, a Transcription Factor for Stress Response and Beyond (2020, background): “Activating transcription factor 4 (ATF4) can dimerize with NRF2 at ARE to induce expression of HO-1 [54].”
• NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis (2019, background): “glutathione-S-transferases pi 1 and alpha 1, GSTP1 and GSTA1; peroxiredoxins 1 and 6, PRDX1 and PRDX6; and thioredoxin reductase, TXNRD1) are also targets of NRF2 [38].”
• Transcriptional Regulation by Nrf2 (2017, background): “Additionally, Nrf2 can also influence cellular elimination of xenobiotics by controlling the expression of many phase I and phase II drug-metabolizing enzymes (49), as well as the multi-drug-resistance-associated transporters (Mrps) (99, 188).”
• Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives (2015, neutral): “There is considerable experimental evidence suggesting that Nrf2 is controlled through a complex transcriptional/epigenetic and post-translational network that ensures its activity increases in response to redox disturbances, inflammation, growth factor stimulation and nutrient/energy fluxes, orches”
• The emerging role of Nrf2 in mitochondrial function (2015, background): “…and the newly synthesized Nrf2 accumulates and translocates to the nucleus. to the nucleus (Fig.1B), where it forms a heterodimer with a small Maf protein; binds to antioxidant-response elements, the upstream regulatory regions of its target genes; and initiates transcription [14 – 16].”