PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

By Jiwang Zhang, J. Grindley, Tong Yin, Sachintha Jayasinghe, Xi C. He, J. Ross, J. Haug, Dawn E Rupp, Kimberly S. Porter-Westpfahl, L. Wiedemann and 2 more. Nature, 2006

849 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/562a0a0f9dd348cb29c3193d568392cd34d79e1c

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Citations in the corpus

Comparing antibody and small-molecule therapies for cancer (2006, background): “Furthermore, a new aspect of cancer-targeted therapies has been provided by recent findings with cancer stem cells that show that mTOR inhibition by rapamycin selectively eliminates leukaemic stem cells without affecting normal haematopoietic stem cell”
Stems cells and the pathways to aging and cancer. (2008, background): “These results suggest that LSCs can emerge from committed hematopoietic progenitor cells without widespread reprogramming of gene expression, through the activation of only a critical subset of self-renewal genes.”
The PTEN–PI3K pathway: of feedbacks and cross-talks (2008, background): “Downstream PI3K, members of the FOXO family can inhibit PP2A phosphatase, thereby increasing AKT phosphorylation (Ni et al., 2007), and activated S6K can overcome the effect of AKT inactivation through direct phosphorylation of GSK3 (Zhang et al., 2006a).”
A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival (2014, methodology): “Next, we performed two additional full screens using cell lines representative of other molecular subtypes of AML: Kasumi1 (carrying a t(8;21) translocation, the cytogenetic hallmark of a RUNX1-RUNX1T1 fusion) and U937”
Mechanisms of stem cell self-renewal. (2009, background): “F or p er so na l u se o nl y. of these cells, rather than their expansion (Yilmaz et al. 2006, Zhang et al. 2006).”
Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, neutral): “Nonetheless, in mammals, recent attention has been drawn to the subtle roles that PTEN signaling plays in abnormal stem cell proliferation and its participation in carcinogenesis (Janzen and Scadden, 2006; Polyak and Hahn, 2006; Rossi and Weissman, 2006; Yilmaz et al., 2006; Zhang et al., 2006).”