Characterization of the piRNA Complex from Rat Testes

By N. Lau, A. Seto, Jinkuk Kim, Satomi Kuramochi‐Miyagawa, T. Nakano, David P. Bartel, Robert E. Kingston. Science, 2006

1,041 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/55eee921794c0f6458bb59d0a894dad2d2856bc5

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In Cancer Research

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In Molecular Biology

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In Plant Science

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Citations in the corpus

• A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice (2008, background): “791 Genomic Origins of Prenatal piRNAs Derivation from clustered loci in the genome has been a defining feature of piRNAs, and these loci play an important role in piRNA generationinbothDrosophilaandvertebrates(Aravinetal.,2006, 2007b; Brennecke et al., 2007; Girard et al., 2006; Lau et al., 2006 )”
• Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans. (2006, background): “These have been annotated as tiny noncodingRNAs(tncRNAs;Ambrosetal.,2003).Infliesandmammals, other distinct classes of small RNAs have been reported, including repeat-associated siRNAs (rasiRNAs; Aravin et al., 2003; Vagin et al., 2006) and Piwi-interacting RNAs (piRNAs; Aravin et al., 2006; Girard ”
• MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. (2007, background): “…others identified small RNA binding partners for Piwi proteins in the male germline, designated as piRNAs (Piwi-interacting RNAs) (Aravin et al., 2006; Girard et al., 2006; Grivna et al., 2006; Lau et al., 2006; Watanabe et al., 2006). piRNAs show distinctive localization patterns in the genome.”
• Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. (2008, background): “In several animals, Piwi-interacting RNAs (piRNAs) show a strong preference for a 50 U (Aravin et al., 2006; Girard et al., 2006; Grivna et al., 2006; Lau et al., 2006).”
• Distinguishing protein-coding and noncoding genes in the human genome (2007, result): “This is in contrast to piRNAs in adult testis of other mammals, which are depleted of repeat sequences and have no known function (Aravin et al. 2006; Girard et al. 2006; Grivna et al. 2006; Lau et al. 2006; Watanabe et al. 2006).”