A decade after SARS: Strategies to control emerging coronaviruses

By Rachel L. Graham, Eric F. Donaldson, Ralph S. Baric. Nature Reviews Microbiology, 2013

665 citations recorded by the source corpus.

Two novel coronaviruses have emerged in humans in the twenty-first century: severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), both of which cause acute respiratory distress syndrome (ARDS) and are associated with high mortality rates. There are no clinically approved vaccines or antiviral drugs available for either of these infections; thus, the development of effective therapeutic and preventive strategies that can be readily applied to new emergent strains is a research priority. In this Review, we describe the emergence and identification of novel human coronaviruses over the past 10 years, discuss their key biological features, including tropism and receptor use, and summarize approaches for developing broadly effective vaccines.

Subfields: Animal Science and Zoology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/b62d0445be53d064af8a952413439811ddbf05ba

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Citations in the corpus

Coronavirus disease 2019 (COVID-19): current status and future perspectives (2020, background): “002, an outbreak of SARS was first reported in China and then pread quickly worldwide, resulting in hundreds of deaths with an 1% mortality rate [3 , 4] .”
SARS-like WIV1-CoV poised for human emergence (2016, background): “Whereas prevailing research suggests that SARSCoV emerged from viruses in the Chinese horseshoe bat, identifying a progenitor strain that used human angiotensin converting enzyme 2 (ACE2) had proven elusive (3, 4).”
Novel 2019 coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment (2020, background): “There are several drugs against SARS-CoV, MERS-CoV tested in animals, and infected viral cell in lab and proteins vaccines (Graham et al., 2013).”
Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19) (2020, background): “Recombinant Subunit Vaccine In general, subunit vaccines are advantageous over other types of vaccines in that they are highly safe and have fewer side effects by inducing the immune system without introducing infectious viruses [12].”
Molecular immune pathogenesis and diagnosis of COVID-19 (2020, positive): “There are several vaccination strategies against SARS-CoV, MERS-CoV tested in animals, including a live-attenuated virus, viral vectors, inactivated virus, subunit vaccines, recombinant DNA, and proteins vaccines [73].”
Impact of the COVID-19 Pandemic on Mental Health and Quality of Life among Local Residents in Liaoning Province, China: A Cross-Sectional Study (2020, background): “The SARS epidemic caused >8000 infections and 800 deaths worldwide (in 26 countries) [7,8].”
From SARS to MERS, Thrusting Coronaviruses into the Spotlight (2019, neutral): “in Nature Reviews Microbiology, 2013 [77]).”
AI-assisted CT imaging analysis for COVID-19 screening: Building and deploying a medical AI system (2020, neutral): “COVID-19 causes acute respiratory istress syndrome on patients [2,3].”
SARS-CoV-2: A Storm is Raging. (2020, neutral): “Of the six coronavirus species previously known to cause human diseases, four typically cause common cold symptoms and two – severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) – can cause fatal respiratory disease (9, 10).”
Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia (2020, result): “Similar to other coronaviral pneumonia such as severe acute respiratory syndrome caused by coronavirus and Middle East respiratory syndrome coronavirus, COVID-19 can also lead to acute respiratory distress syndrome (ARDS) (1, 5).”