Presence of B cells in tertiary lymphoid structures is associated with a protective immunity in patients with lung cancer.
By C. Germain, S. Gnjatic, Fella Tamzalit, Samantha Knockaert, R. Remark, J. Goc, A. Lepelley, Etienne Becht, S. Katsahian, G. Bizouard and 9 more. American Journal of Respiratory and Critical Care Medicine, 2014
709 citations recorded by the source corpus.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/33efa86628b48a641ba68521c65f329d72236158
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- Ton N. Schumacher
- D. Thommen
- Padmanee Sharma
- James P. Allison
- C. Blank
- C. Sautès-Fridman
- Nir Hacohen
- K. Rezvani
In Oncology
- Ton N. Schumacher
- D. Thommen
- Padmanee Sharma
- C. Sautès-Fridman
- C. Blank
- James P. Allison
- D. Peeper
- Raghu Kalluri
Citations in the corpus
- Tumor-infiltrating lymphocytes in the immunotherapy era (2020, background): “156 Although the described functional capacities of TFH cells and FDCs are mainly applicable in SLOs, the presence of these cells in TLSs has been identified, and similar functioning is assumed.82,157–159 Cellular & Molecular Immunology (2021) 18:842 – 859 TLSs are mostly located peritumorally in th”
- Tertiary lymphoid structures in cancer (2022, background): “Furthermore, evidence that clonal proliferation, isotype switching, and B cell effector differentiation actively take place in TLSs is provided by the detection of activationinduced cytidine deaminase, the enzymedriving somatic hypermutation and class switching, and BCL6, the transcription factor co”
- B cells and tertiary lymphoid structures promote immunotherapy response (2020, positive): “…with existing data regarding a potential prognostic role for TLS in melanoma and other cancer types outside the context of treatment with ICB 18,34,35 , we next assessed the expression of these immune related genes in cutaneous melanoma from The Cancer Genome Atlas platform (TCGA-SKCM, n=136) 36 .”
- Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression (2016, background): “In lung non-small cell adenocarcinoma, it was recently reported that infiltration by B or T cells independently predicts favorable prognosis [16, 17].”