Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress

By T. Bale, A. Contarino, George W. Smith, Raymond K. W. Chan, L. Gold, P. Sawchenko, G. Koob, W. Vale, Kuo-Fen Lee. Nature Genetics, 2000

871 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Social Psychology

View Paper: https://www.semanticscholar.org/paper/54dcb2cab0b0789e11cacbf557b2e74f895f0a09

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Citations in the corpus

The Corticosteroid Receptor Hypothesis of Depression (2000, background): “In contrast, CRH-R2 deficiency was shown to increase anxiety-like behavior in some (Bale et al. 2000; Kishimoto et al. 2000) but not all (Coste et al.”
Sex-Specific Programming of Offspring Emotionality after Stress Early in Pregnancy (2008, methodology): “Audrey Seasholtz, University of Michigan, Ann Arbor, MI) or CRF probes as previously described (Bale et al., 2000).”
Model organisms: The ascent of mouse: advances in modelling human depression and anxiety (2005, neutral): “The effectiveness of a test battery approach is further advocated by evidence that even among the ostensibly similar exploration-based mouse tasks, there are qualitative differences between tests, with each test measuring overlapping, but partially distinct, forms of anxiety-related behaviou”
The Neurobiology of Parental Behavior (2003, background): “, 1999) and R2 knockouts manifest increased anxiety (Bale et al., 2000), neither genotype has been reported to show altered maternal behavior.”
Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor (2001, background): “, whereas CRHR2 mediates stress-coping responses including anxiolysis, anorexia, hypotension, cardioprotection and dearousa”
Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2 (2000, result): “Our results showing normal anxiety responses in Crhr2 −/− mice differ from those reported in an accompanying pape”
Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. (2005, background): “However, these results could have been produced by developmental compensations, and indeed, Bale et al. (2000) found elevated levels of CRH and UCN in the genetically altered subjects.”
Neuroendocrine pharmacology of stress. (2003, background): “Ten minutes after the onset of stress, corticosterone levels continued to rise in the CRF2 mutant mice reaching higher levels than in the wild type (Bale et al., 2000; Coste et al., 2000).”
Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse (2000, background): “Mouse strains bearing targeted null mutations of CRF (Muglia et al., 1995), CRF-R1 (Smith et al., 1998), CRF-R2 (Bale et al., 2000; Coste et al., 2000; Kishimoto et al., 2000) and the CRF-binding protein (Karolyi et al., 1999) have been generated, and display phenotypes that have already begun to…”