Phenotypic characterization of human colorectal cancer stem cells

By Piero Dalerba, S. Dylla, In-kyung Park, Rui Liu, Xinhao Wang, Robert W. Cho, T. Hoey, A. Gurney, E. Huang, D. Simeone and 4 more. Proceedings of the National Academy of Sciences of the United States of America, 2007

2,261 citations recorded by the source corpus.

Subfields: Cancer Research, Cell Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/54ceb2f5601b1c7672153bcab70e4cc01aee11c1

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Citations in the corpus

SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma (2009, background): “Similarly, it has been proposed that CD44 can be an enrichment marker for colon and prostate cancer TICs (Dalerba et al., 2007; Patrawala et al., 2007).”
Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment (2018, background): “Several cell surface markers have been verified to identify CSCenriched populations, such as CD133, CD24, CD44, EpCAM (epithelial cell adhesion molecule), THY1, ABCB5 (ATP-binding cassette B5), and CD200 [27, 32, 34, 52].”
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions (2008, background): “On the other hand, the EpCAM hi CD44 + CSC subset in colorectal cance”
Cancer stem cells: impact, heterogeneity, and uncertainty. (2012, result): “…studies have taken similar approaches to provide evidence that other human cancers also follow the cancer stem cell model, including colon cancer (Dalerba et al., 2007; O’Brien et al., 2007; Ricci-Vitiani et al., 2007), pancreatic cancer (Li et al., 2007), brain tumors (Bao et al., 2006;…”
Cancer stem cells: current status and evolving complexities. (2012, background): “A similar story holds true for colorectal cancer in which the EpCAMhiCD44+ CSC subpopulation shared minor overlap with CD133 (Dalerba et al., 2007), and for pancreatic cancer, where overlap between the CD133+ and CD44+CD24+ populations varied considerably between specimens (Hermann et al., 2007).”
Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis (2009, methodology): “assays were done as we previously described (9).”
Down-regulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells (2009, background): “…head and neck, skin, and brain cancer, a cancer stem cell population can be enriched based on phenotype (Al-Hajj et al., 2003; Cho et al., 2008; Dalerba et al., 2007; Lapidot et al., 1994; Malanchi et al., 2008; O’Brien et al., 2007; Prince et al., 2007; Ricci-Vitiani et al., 2007; Singh et…”
Multicellular tumor spheroids: an underestimated tool is catching up again. (2010, background): “Human cancers ecently described as having such subpopulations of cells include ot only cancers of the blood but also solid malignancies of brain, reast, pancreas, colon, and head and neck (Cho and Clarke, 2008; alerba et al., 2007; Lee et al., 2006; Ricci-Vitiani et al., 2009).”
Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity (2008, background): “Fodde, unpublished data) (8), were also expressed on a subpopulation in those spheroid cultures (Fig.”
Single-cell dissection of transcriptional heterogeneity in human colon tumors (2011, methodology): “We injected NOD/SCID/IL2Rγ −/− mice with single ( n =1) EpCAM high /CD44 + cancer cells purified by flow cytometry from one of our well-characterized solid xenograft line”
Heterogeneity in cancer: cancer stem cells versus clonal evolution. (2009, background): “…in leukemias (Lapidot et al., 1994; Bonnet and Dick, 1997), breast cancers (Al-Hajj et al., 2003), brain cancers (Singh et al., 2004), and colon cancers (Dalerba et al., 2007; O’Brien et al., 2007; RicciVitiani et al., 2007) is strong evidence that these cancers follow a cancer stem cell model.”