Involvement of chemokine receptors in breast cancer metastasis

By A. Müller, B. Homey, H. Soto, Nianfeng Ge, D. Catron, Matthew E. Buchanan, T. Mcclanahan, E. Murphy, W. Yuan, S. Wagner and 4 more. Nature, 2001

5,518 citations recorded by the source corpus.

Subfields: Immunology, Immunology and Allergy, Oncology

View Paper: https://www.semanticscholar.org/paper/53d4cf7a9c426d39a274ede335ed7624de504621

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In Immunology

1. A. Mantovani
2. A. Sica
3. P. Allavena
4. J. Joyce
5. Subhra K. Biswas
6. J. Talmadge
7. I. J. Fidler
8. J. Van Damme

In Immunology and Allergy

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4. M. Shibuya
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6. M. Egeblad
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In Oncology

1. J. Massagué
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4. A. Mantovani
5. J. Talmadge
6. A. Sica
7. I. J. Fidler
8. J. Joyce

Citations in the corpus

• Molecular mechanisms of lymphangiogenesis in health and disease. (2002, background): “Indeed, attraction of CCR7-positive tumor cells to SLC-expressing lymphatic endothelium enhanced lymph node metastasis (Muller et al., 2001).”
• Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. (2007, background): “…these gradients of SDF-1 may attract tumor cells and regulate proliferation and invasion at specific metastatic sites (Bachelder et al., 2002; Muller et al., 2001; Schneider et al., 2002), which has been shown for pancreatic cancer in a mouse model of experimental metastasis (Saur et al.,…”
• Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. (2011, background): “Molecules that play critical roles in HSC niche selection are now thought to be used by metastases to establish footholds in the BM (2, 3), including chemoattractants (CXCL12; also referred to as stromal-derived factor–1; refs.”
• G protein-coupled receptors: novel targets for drug discovery in cancer (2010, background): “Furthermore, CXCL12 activates CXCR4, which is highly expressed in frequently metastatic site”
• Regulation of the Chemokine Receptor CXCR4 by Hypoxia (2003, background): “CXCR4 expression by cancer cells may play an important role in the metastatic process (33).”
• A multigenic program mediating breast cancer metastasis to bone. (2003, background): “Thus, the populations that are highly meta- static to bone have a distinct transcriptional signature not shared (Muller et al., 2001; Taichman et al., 2002); the angiogenesis factors fibroblast growth factor-5 (Giordano et al., 1996) andby populations that are highly metastatic to the adrenal gland.”
• Imaging in the era of molecular oncology (2008, background): “…promotes carcinoma cell growth by direct paracrine stimulation of the chemokine receptor CXCR4 on tumour cells; it recruits endothelial progenitor cells from the blood vessels, giving rise to highly vascularized tumours; and it supports the metastasis of tumour cells towards lymphatic vessels55,57.”
• The chemokine and chemokine receptor superfamilies and their molecular evolution (2006, background): “The importance of the chemokines has grown in recent years, as it has become recognized that they are key players in many disease processes, including inflammation, autoimmune disease, infectious diseases (such as HIV/AIDS), and more recently, cancer (in particular in regulating metastasis) [3].”