The chemokine and chemokine receptor superfamilies and their molecular evolution

By A. Zlotnik, O. Yoshie, H. Nomiyama. Genome Biology, 2006

624 citations recorded by the source corpus.

The human chemokine superfamily currently includes at least 46 ligands, which bind to 18 functionally signaling G-protein-coupled receptors and two decoy or scavenger receptors. The chemokine ligands probably comprise one of the first completely known molecular superfamilies. The genomic organization of the chemokine ligand genes and a comparison of their sequences between species shows that tandem gene duplication has taken place independently in the mouse and human lineages of some chemokine families. This means that care needs to be taken when extrapolating experimental results on some chemokines from mouse to human.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/8263920fc138d2bfeab902461ba3747679f09a13

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In Immunology

1. Caroline L. Sokol
2. A. Ben-Baruch
3. G. Soria
4. A. Luster

In Molecular Biology

1. S. Gill
2. W. Parks
3. Caroline L. Sokol
4. A. Luster

In Oncology

1. S. Gill
2. Caroline L. Sokol
3. A. Ben-Baruch
4. G. Soria
5. W. Parks
6. A. Luster

Citations in the corpus

• International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “CCR9 is a homeostatic receptor specific for CCL25 (previously called thymus expressed chemokine) (Zaballos et al., 1999; Norment et al., 2000; Zlotnik et al., 2006), a chemokine strongly expressed in the thymus and to a lesser extent in the small intestine (Vicari et al., 1997).”
• Metalloproteinases and their inhibitors: regulators of wound healing. (2008, background): “The other main subfamily of chemokines, the CXC chemokines, primarily regulate neutrophil chemotaxis and as their designation implies, have an extra amino acid residue between the first two N-terminal cysteines (Clark-Lewis et al., 1995; Zlotnik et al., 2006).”
• The chemokine system in innate immunity. (2015, background): “Humans and mice contain 17 signaling chemokine receptors, with the majority present on human chromosome 3 (Zlotnik et al. 2006).”
• The Chemokine Superfamily Revisited (2012, neutral): “However, because of the rapid and divergent evolution of the chemokine system, species like humans andmice exhibit differences in their chemokine ligands (Zlotnik et al., 2006).”
• The inflammatory chemokines CCL2 and CCL5 in breast cancer. (2008, background): “As such, the expression of these chemokines is usually inducible by the inflammatory insult, and is shut-off at the resolution of inflammation [9–11].”