The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

By Teresa L. M. Thurston, Grigory Ryzhakov, S. Bloor, Natalia von Muhlinen, F. Randow. Nature Immunology, 2009

881 citations recorded by the source corpus.

Subfields: Endocrinology, Epidemiology, Virology

View Paper: https://www.semanticscholar.org/paper/530900da5898d226ac8d1cb2ab9cf3de86e0aa3a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. D. Klionsky
2. N. Mizushima
3. V. Deretic
4. Beth Levine

In Epidemiology

1. D. Klionsky
2. N. Mizushima
3. I. Slaninová
4. T. Johansen
5. V. Deretic
6. T. Lamark
7. Beth Levine
8. Zhifen Yang

Citations in the corpus

• PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “Kirkin V, et al. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.”
• Autophagy in inflammation, infection, and immunometabolism (2021, background): “, 2008), whereas TBK1 plays a role in autophagy (Kumar et al., 2019; Pilli et al., 2012; Sparrer et al., 2017; Thurston et al., 2009; Wild et al., 2011).”
• Deciphering the Molecular Signals of PINK1/Parkin Mitophagy. (2016, background): “TBK1 and Optineurin also play important roles in xenophagy [49,58] and have been shown to contribute to inflammatory pathways [59,60], highlighting the complexity of neurodegeneration in ALS and glaucoma.”
• Selective autophagy: ubiquitin-mediated recognition and beyond (2010, background): “Finally, ubiquitylation targets bacteria for destruction in the lysosomal compartment, providing an important cellular defence mechanism to fight infection”
• Eaten alive: a history of macroautophagy (2010, background): “Randow's laboratory provided further evidence that a human autophagy receptor, NDP52 (nuclear dot protein 52 K), detects ubiquitin-coated Salmonella enterica and directs this bacteria into autophagosomes by simultaneously binding to LC3 (ref”
• Autophagy gone awry in neurodegenerative diseases (2010, neutral): “, whereas NDP52 recognizes ubiquitin-coated bacteria inside human cell”
• Molecular definitions of autophagy and related processes (2017, neutral): “…including p62, OPTN, NDP52, and Tax1-binding protein 1 (TAX1BP1), via a mechanism that relies on receptor phosphorylation by TANK1-binding kinase 1 (TBK1) (Thurston et al , 2009; Wild et al , 2011; Tumbarello et al , 2015) and ubiquitination by ring finger protein 166 (RNF166) (Heath et al , 2016).”